CD163 M130 Polyclonal Antibody Cy5 Conjugated
Cat# MBS9461072-5x0,1mL
Size : 5x0.1mL
Brand : MyBiosource
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CD163 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9461072Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via… More details
Product Overview
Online Datasheet in PDFProduct Name
CD163 M130, Polyclonal Antibody
Full Product Name
CD163 M130 Polyclonal Antibody Cy5 Conjugated
Product Gene Name
anti-CD163 antibody
Product Synonym Gene Name
M130
Product Synonym Names
M13; MM13; Scavenger receptor cysteine-rich type 1 protein M13; Hemoglobin scavenger receptor; CD163; CD163 M130
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Purity/Purification
Purified by Protein A
Concentration
1mgml (lot specific)
Preparation and Storage
Store at 4 degree C for 12 months.
Applications Tested/Suitable for anti-CD163 antibody
Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-CD163 antibody
FC/FACS:1:20-10
IF: 1:50-200
IF: 1:50-200
Other Notes
Small volumes of anti-CD163 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CD163 purchase
MBS9461072 is an antibody targeting CD163. Also known as CD163 M130 Polyclonal Antibody Cy5 Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for CD163. It may not necessarily be applicable to this product.
NCBI Official Full Name
scavenger receptor cysteine-rich type 1 protein M130 isoform a
NCBI Official Synonym Full Names
CD163 molecule
NCBI Official Symbol
CD163
NCBI Official Synonym Symbols
M130; MM130
UniProt Protein Name
Scavenger receptor cysteine-rich type 1 protein M130
UniProt Synonym Protein Names
Hemoglobin scavenger receptor
Protein Family
Scavenger receptor cysteine-rich type 1 protein
UniProt Gene Name
CD163
UniProt Synonym Gene Names
M130; sCD163
UniProt Entry Name
C163A_HUMAN
NCBI Protein Information
scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen
NCBI Summary for CD163
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Show more UniProt Comments for CD163
CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: protein binding; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; acute-phase response
Show more Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: protein binding; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; acute-phase response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CD163 antibody
| Reference Product | PubMed Publications |
|---|---|
| CD68 antibody | >364 publications with CD163 and CD68 |
| IL10 antibody | >92 publications with CD163 and IL10 |
| HMOX1 antibody | >42 publications with CD163 and HMOX1 |
| CSF1R antibody | >28 publications with CD163 and CSF1R |
| IL6 antibody | >11 publications with CD163 and IL6 |
| C1QB antibody | >1 publications with CD163 and C1QB |
| VSIG4 antibody | >1 publications with CD163 and VSIG4 |
Pathways associated with anti-CD163 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies | Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram |
| Scavenging Of Heme From Plasma Pathway antibodies | Scavenging Of Heme From Plasma Pathway Diagram |
Diseases associated with anti-CD163 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >354 publications with CD163 and Inflammation |
| Neoplasms Antibodies | >254 publications with CD163 and Neoplasms |
| Necrosis Antibodies | >157 publications with CD163 and Necrosis |
| Nervous System Diseases Antibodies | >102 publications with CD163 and Nervous System Diseases |
| Brain Diseases Antibodies | >63 publications with CD163 and Brain Diseases |
| Fibrosis Antibodies | >55 publications with CD163 and Fibrosis |
| Lung Diseases Antibodies | >46 publications with CD163 and Lung Diseases |
| Adenocarcinoma Antibodies | >39 publications with CD163 and Adenocarcinoma |
| Heart Diseases Antibodies | >29 publications with CD163 and Heart Diseases |
| Kidney Diseases Antibodies | >27 publications with CD163 and Kidney Diseases |
Organs/Tissues associated with anti-CD163 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >592 publications with CD163 and Blood |
| Vascular Antibodies | >167 publications with CD163 and Vascular |
| Skin Antibodies | >108 publications with CD163 and Skin |
| Bone Antibodies | >100 publications with CD163 and Bone |
| Liver Antibodies | >99 publications with CD163 and Liver |
| Brain Antibodies | >70 publications with CD163 and Brain |
| Lung Antibodies | >68 publications with CD163 and Lung |
| Connective Tissue Antibodies | >46 publications with CD163 and Connective Tissue |
| Heart Antibodies | >40 publications with CD163 and Heart |
| Spleen Antibodies | >39 publications with CD163 and Spleen |