CD54 (ICAM-1, Intercellular Adhesion Molecule 1, Human Rhinovirus Receptor, Precursor, BB2, Major Group Rhinovirus Receptor, P3.58) (AP)
Cat# MBS6247708-0,1mL
Size : 0.1mL
Brand : MyBiosource
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CD54 (ICAM-1, Intercellular Adhesion Molecule 1, Human Rhinovirus Receptor, Precursor, BB2, Major Group Rhinovirus Receptor, P3.58) (AP)
FFPE human spleen stained with C2409-14B, biotinylated Anti-Mouse IgG and Streptavidin Alkaline Phosphatase (red). Nuclei were counterstained with hematoxylin.
CD54 Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6247708MBS6247708 is an antibody targeting CD54. Also known as CD54 (ICAM-1, Intercellular Adhesion Molecule 1, Human Rhinovirus Receptor, Precursor, BB2, Major Group Rhinovirus Receptor, P3.58) (AP). Reactive in Human, Porcine. Host: Mouse. More details
Product Overview
Online Datasheet in PDFProduct Name
CD54, Monoclonal Antibody
Full Product Name
CD54 (ICAM-1, Intercellular Adhesion Molecule 1, Human Rhinovirus Receptor, Precursor, BB2, Major Group Rhinovirus Receptor, P3.58) (AP)
Product Gene Name
anti-CD54 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3H1547
Host
Mouse
Species Reactivity
Human, Porcine
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes human CD54, a 90kD glycoprotein. Blocks CD54 function. Species Crossreactivity: porcine
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Applications Tested/Suitable for anti-CD54 antibody
Immunohistochemistry (IHC), Immunoprecipitation (IP)
Product References and Citations for anti-CD54 antibody
1. J. Cell Biol. (1992) 116: 1527-1535. 2. Cell (1992) 68: 71-81. 3. Treadwell, M.D. et al. (1996). Increased neutrophil adherence to endothelial cells exposed to asbestos. Toxicol Appl. Pharmacol. 139: 62-70.
Other Notes
Small volumes of anti-CD54 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CD54. It may not necessarily be applicable to this product.
NCBI Official Full Name
intercellular adhesion molecule 1
NCBI Official Synonym Full Names
intercellular adhesion molecule 1
NCBI Official Symbol
ICAM1
NCBI Official Synonym Symbols
BB2; CD54; P3.58
UniProt Protein Name
Intercellular adhesion molecule 1
UniProt Synonym Protein Names
Major group rhinovirus receptor
Protein Family
Intercellular adhesion molecule
UniProt Gene Name
ICAM1
UniProt Synonym Gene Names
ICAM-1
UniProt Entry Name
ICAM1_HUMAN
NCBI Protein Information
intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
NCBI Summary for CD54
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for CD54
ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.
Protein type: Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: extracellular space; cell surface; focal adhesion; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane
Molecular Function: integrin binding; viral receptor activity; protein binding; transmembrane receptor activity; receptor activity
Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; regulation of cell adhesion; response to drug; virion attachment, binding of host cell surface receptor; regulation of immune response; negative regulation of calcium ion transport; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; cell adhesion mediated by integrin; adhesion to host; response to ionizing radiation; leukocyte migration
Disease: Malaria, Susceptibility To
Show more Protein type: Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: extracellular space; cell surface; focal adhesion; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane
Molecular Function: integrin binding; viral receptor activity; protein binding; transmembrane receptor activity; receptor activity
Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; regulation of cell adhesion; response to drug; virion attachment, binding of host cell surface receptor; regulation of immune response; negative regulation of calcium ion transport; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; cell adhesion mediated by integrin; adhesion to host; response to ionizing radiation; leukocyte migration
Disease: Malaria, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CD54 antibody
| Reference Product | PubMed Publications |
|---|---|
| ITGB2 antibody | >860 publications with CD54 and ITGB2 |
| ITGAL antibody | >467 publications with CD54 and ITGAL |
| ITGAM antibody | >423 publications with CD54 and ITGAM |
| CD44 antibody | >356 publications with CD54 and CD44 |
| ITGAX antibody | >134 publications with CD54 and ITGAX |
| IL6 antibody | >115 publications with CD54 and IL6 |
| SELE antibody | >59 publications with CD54 and SELE |
| HLA-B antibody | >28 publications with CD54 and HLA-B |
| DIF antibody | >3 publications with CD54 and DIF |
Pathways associated with anti-CD54 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Adaptive Immune System Pathway antibodies | Adaptive Immune System Pathway Diagram |
| African Trypanosomiasis Pathway antibodies | African Trypanosomiasis Pathway Diagram |
| African Trypanosomiasis Pathway antibodies | African Trypanosomiasis Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cytokine Signaling In Immune System Pathway antibodies | Cytokine Signaling In Immune System Pathway Diagram |
| Epstein-Barr Virus Infection Pathway antibodies | Epstein-Barr Virus Infection Pathway Diagram |
| Epstein-Barr Virus Infection Pathway antibodies | Epstein-Barr Virus Infection Pathway Diagram |
| Glucocorticoid Receptor Regulatory Network Pathway antibodies | Glucocorticoid Receptor Regulatory Network Pathway Diagram |
| HTLV-I Infection Pathway antibodies | HTLV-I Infection Pathway Diagram |
Diseases associated with anti-CD54 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >5074 publications with CD54 and Inflammation |
| Necrosis Antibodies | >4440 publications with CD54 and Necrosis |
| Cardiovascular Diseases Antibodies | >3300 publications with CD54 and Cardiovascular Diseases |
| Atherosclerosis Antibodies | >1309 publications with CD54 and Atherosclerosis |
| Reperfusion Injury Antibodies | >810 publications with CD54 and Reperfusion Injury |
| Myocardial Ischemia Antibodies | >740 publications with CD54 and Myocardial Ischemia |
| Kidney Diseases Antibodies | >717 publications with CD54 and Kidney Diseases |
| Liver Diseases Antibodies | >511 publications with CD54 and Liver Diseases |
| Asthma Antibodies | >475 publications with CD54 and Asthma |
| Hypertension Antibodies | >474 publications with CD54 and Hypertension |
Organs/Tissues associated with anti-CD54 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >11071 publications with CD54 and Blood |
| Vascular Antibodies | >8225 publications with CD54 and Vascular |
| Lung Antibodies | >1634 publications with CD54 and Lung |
| Heart Antibodies | >1179 publications with CD54 and Heart |
| Skin Antibodies | >1167 publications with CD54 and Skin |
| Liver Antibodies | >1108 publications with CD54 and Liver |
| Kidney Antibodies | >1098 publications with CD54 and Kidney |
| Brain Antibodies | >1085 publications with CD54 and Brain |
| Muscle Antibodies | >959 publications with CD54 and Muscle |
| Embryonic Tissue Antibodies | >755 publications with CD54 and Embryonic Tissue |