Collagen Type V, Human
Cat# MBS634669-5x0,1mg
Size : 5x0.1mg
Brand : MyBiosource
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Collagen Type V (COL5A2) Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634669MBS634669 is a protein targeting COL5A2. Also known as Collagen Type V, Human. Host: Placental villi. More details
Product Overview
Online Datasheet in PDFProduct Name
Collagen Type V (COL5A2), Protein
Full Product Name
Collagen Type V, Human
Product Gene Name
COL5A2 protein
Host
Placental villi
Form/Format
Supplied as a lyophilized powder.
Purity/Purification
Purified
Controlled and limited pepsin digestion, followed by selective salt precipitation. > 90% as judged by SDS-PAGE analysis.
Controlled and limited pepsin digestion, followed by selective salt precipitation. > 90% as judged by SDS-PAGE analysis.
Preparation and Storage
Purified collagen may be stored at 2-8 degree C for several months without appreciable loss of activity. For long-term storage, the purified collagen may be aliquoted and stored at -20 degree C. Avoid repeated freezing and thawing.
Molecular Weight
144,910 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (189896641..190044668, complement). Location: 2q14-q32
OMIM
120190
Reconstitution
The collagen may be reconstituted by re-suspending in 500mM acetic acid. The collagen may be transferred into physiological buffers by dialysis at 2-8 degree C.
Product Categories/Family for COL5A2 protein
Molecular Biology; MB-Collagen
Application Notes for COL5A2 protein
Type V collagen standard, , Antigen for antibody production, , Coating material for cell culture studies, , Formation of collagen gels
Other Notes
Small volumes of COL5A2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for COL5A2. It may not necessarily be applicable to this product.
NCBI Official Full Name
collagen type V alpha-2, partial
NCBI Official Synonym Full Names
collagen, type V, alpha 2
NCBI Official Symbol
COL5A2
UniProt Protein Name
Collagen alpha-2(V) chain
Protein Family
Collagen
UniProt Gene Name
COL5A2
UniProt Entry Name
CO5A2_HUMAN
NCBI Protein Information
collagen alpha-2(V) chain; collagen alpha-2(V) chain; AB collagen; type V preprocollagen alpha 2 chain; collagen, fetal membrane, A polypeptide
NCBI Summary for COL5A2
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for COL5A2
COL5A2: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q14-q32
Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region
Molecular Function: metal ion binding; extracellular matrix structural constituent; SMAD binding
Biological Process: skin development; axon guidance; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; ossification; collagen fibril organization; skeletal development; eye morphogenesis
Disease: Ehlers-danlos Syndrome, Type I
Show more Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q14-q32
Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region
Molecular Function: metal ion binding; extracellular matrix structural constituent; SMAD binding
Biological Process: skin development; axon guidance; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; ossification; collagen fibril organization; skeletal development; eye morphogenesis
Disease: Ehlers-danlos Syndrome, Type I
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with COL5A2 protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies | Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram |
| Collagen Biosynthesis And Modifying Enzymes Pathway antibodies | Collagen Biosynthesis And Modifying Enzymes Pathway Diagram |
| Collagen Formation Pathway antibodies | Collagen Formation Pathway Diagram |
| ECM-receptor Interaction Pathway antibodies | ECM-receptor Interaction Pathway Diagram |
| ECM-receptor Interaction Pathway antibodies | ECM-receptor Interaction Pathway Diagram |
| Extracellular Matrix Organization Pathway antibodies | Extracellular Matrix Organization Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
Diseases associated with COL5A2 protein
| Disease Name | Pubmed Publications |
|---|---|
| Cardiovascular Diseases Antibodies | >29 publications with COL5A2 and Cardiovascular Diseases |
| Neoplasms Antibodies | >9 publications with COL5A2 and Neoplasms |
| Ehlers-Danlos syndrome type 1 Antibodies | >8 publications with COL5A2 and Ehlers-Danlos syndrome type 1 |
| Fibrosis Antibodies | >6 publications with COL5A2 and Fibrosis |
| Nervous System Diseases Antibodies | >5 publications with COL5A2 and Nervous System Diseases |
| Brain Diseases Antibodies | >3 publications with COL5A2 and Brain Diseases |
| Carcinoma Antibodies | >3 publications with COL5A2 and Carcinoma |
| Disease Models, Animal Antibodies | >3 publications with COL5A2 and Disease Models, Animal |
| Breast Neoplasms Antibodies | >3 publications with COL5A2 and Breast Neoplasms |
| Hypertension Antibodies | >2 publications with COL5A2 and Hypertension |
Organs/Tissues associated with COL5A2 protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Connective Tissue Antibodies | >22 publications with COL5A2 and Connective Tissue |
| Skin Antibodies | >21 publications with COL5A2 and Skin |
| Bone Antibodies | >9 publications with COL5A2 and Bone |
| Vascular Antibodies | >7 publications with COL5A2 and Vascular |
| Heart Antibodies | >5 publications with COL5A2 and Heart |
| Eye Antibodies | >5 publications with COL5A2 and Eye |
| Muscle Antibodies | >5 publications with COL5A2 and Muscle |
| Kidney Antibodies | >3 publications with COL5A2 and Kidney |
| Mouth Antibodies | >2 publications with COL5A2 and Mouth |
| Intestine Antibodies | >1 publications with COL5A2 and Intestine |