Biovalley > DES Antibody - HRP
DES Antibody - HRP
Brand : Aviva Systems Biology
DES Antibody : HRP (OABF00394-HRP)
| Datasheets/Manuals | Printable datasheet for OABF00394-HRP |
|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Chicken |
|---|---|
| Product Format | Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | HRP: Horseradish Peroxidase |
| Application | WB, IHC-P, IF, ICC |
| Additional Information | Subcellular location: Cytoplasm |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | KLH conjugated synthetic peptide derived from human Desmin |
| Purification | Purified by Protein A. |
| Concentration | 0.6-0.7 mg/ml |
| Application Info | WB(1:100-1000) IHC-P(1:100-500) IF(1:50-200) |
| Gene Symbol | DES |
|---|---|
| Gene Full Name | desmin |
| Alias Symbols | CSM1, CSM2, CDCD3, LGMD1D, LGMD1E, LGMD2R |
| NCBI Gene Id | 1674 |
| Description of Target | Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. |
| Uniprot ID | P17661 |
Protein interactions
| Name | # of Products |
|---|---|
| AURKB | 77 |
| CAPN1 | 124 |
| DSP | 76 |
| NEB | 24 |
| PKD1 | 63 |
| PLEKHA5 | 48 |
| ROCK1 | 55 |
| S100A1 | 60 |
| S100B | 59 |
| SHBG | 104 |
| SPTAN1 | 98 |
| SYNC | 7 |
| SYNM | 7 |
| TRIM7 | 8 |
| UBC | 7030 |
| YWHAQ | 716 |
Biological pathways
| Name | # of Products |
|---|---|
| Cytoskeleton organization | 135 |
| Muscle filament sliding | 73 |
| Regulation of heart contraction | 36 |
Biological process
| Name | # of Products |
|---|---|
| Cytoskeleton organization | 97 |
| Muscle contraction | 66 |
| Muscle filament sliding | 28 |
| Regulation of heart contraction | 31 |
Cellular components
| Name | # of Products |
|---|---|
| Contractile fiber | 12 |
| Cytoplasm | 4549 |
| Cytoskeleton | 630 |
| Cytosol | 1868 |
| Fascia adherens | 12 |
| Insoluble fraction | 39 |
| Intermediate filament | 61 |
| Intracellular | 1678 |
| Neuromuscular junction | 32 |
| Sarcolemma | 57 |
| Type III intermediate filament | 5 |
| Z disc | 54 |
Protein function
| Name | # of Products |
|---|---|
| Nebulin binding | 8 |
| Protein binding | 12191 |
| Structural constituent of cytoskeleton | 188 |
Diseases
| Name | # of Products |
|---|---|
| Cardiomyopathy | 211 |
| Desmin-related myopathy | 13 |
| Disease mutation | 5332 |
| Myofibrillar myopathy | 23 |
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