DSCR1 Antibody
Cat# MBS8583243-0,1mL-PE
Size : 0.1mL(PE)
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
DSCR1 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8583243MBS8583243 is an antibody targeting DSCR1. Also known as DSCR1 Antibody. Reactive in Human, Mouse, Rat, Bovine, Sheep. Host: Rabbit. Rabbit polyclonal antibody to DSCR1 More details
Product Overview
Online Datasheet in PDFProduct Name
DSCR1, Polyclonal Antibody
Full Product Name
DSCR1 Antibody
Product Gene Name
anti-DSCR1 antibody
Product Synonym Gene Name
RCAN1
Product Synonym Names
ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Sheep
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of DSCR1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
28,079 Da
Chromosome Location
Chromosome: 21; NC_000021.8 (35888782..35987382, complement). Location: 21q22.12
OMIM
602917
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DSCR1. The exact sequence is proprietary.
Product Categories/Family for anti-DSCR1 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DSCR1 antibody
Western Blot (WB)
Application Notes for anti-DSCR1 antibody
WB: 1:500-1:1000
Other Notes
Small volumes of anti-DSCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for DSCR1. It may not necessarily be applicable to this product.
NCBI Official Full Name
calcipressin-1 isoform a
NCBI Official Synonym Full Names
regulator of calcineurin 1
NCBI Official Symbol
RCAN1
NCBI Official Synonym Symbols
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
UniProt Protein Name
Calcipressin-1
UniProt Synonym Protein Names
Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
UniProt Gene Name
RCAN1
UniProt Synonym Gene Names
ADAPT78; CSP1; DSC1; DSCR1; MCIP1
UniProt Entry Name
RCAN1_HUMAN
NCBI Protein Information
calcipressin-1; near DSCR proline-rich protein; Down syndrome candidate region 1; calcium and oxidant-inducible mRNA; Down syndrome critical region gene 1; down syndrome critical region protein 1; modulatory calcineurin-interacting protein 1; myocyte-enri
NCBI Summary for DSCR1
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for DSCR1
RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: nucleus
Molecular Function: identical protein binding; protein binding; DNA binding; transcription factor activity
Biological Process: central nervous system development; regulation of transcription, DNA-dependent; blood circulation; calcium-mediated signaling; signal transduction
Show more Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: nucleus
Molecular Function: identical protein binding; protein binding; DNA binding; transcription factor activity
Biological Process: central nervous system development; regulation of transcription, DNA-dependent; blood circulation; calcium-mediated signaling; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-DSCR1 antibody
| Reference Product | PubMed Publications |
|---|---|
| MAPK3 antibody | >2 publications with DSCR1 and MAPK3 |
| UXT antibody | >1 publications with DSCR1 and UXT |
| PPP3CA antibody | >1 publications with DSCR1 and PPP3CA |
| MAP3K3 antibody | >1 publications with DSCR1 and MAP3K3 |
| GSK3B antibody | >1 publications with DSCR1 and GSK3B |
Pathways associated with anti-DSCR1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Calcium Signaling In The CD4+ TCR Pathway antibodies | Calcium Signaling In The CD4+ TCR Pathway Diagram |
| MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies | MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram |
| Notch-mediated HES/HEY Network Pathway antibodies | Notch-mediated HES/HEY Network Pathway Diagram |
| Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies | Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram |
Diseases associated with anti-DSCR1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Down Syndrome Antibodies | >101 publications with DSCR1 and Down Syndrome |
| Nervous System Diseases Antibodies | >64 publications with DSCR1 and Nervous System Diseases |
| Hypertrophy Antibodies | >33 publications with DSCR1 and Hypertrophy |
| Cardiovascular Diseases Antibodies | >27 publications with DSCR1 and Cardiovascular Diseases |
| Neoplasms Antibodies | >19 publications with DSCR1 and Neoplasms |
| Brain Diseases Antibodies | >19 publications with DSCR1 and Brain Diseases |
| Disease Models, Animal Antibodies | >17 publications with DSCR1 and Disease Models, Animal |
| Inflammation Antibodies | >15 publications with DSCR1 and Inflammation |
| Heart Defects, Congenital Antibodies | >8 publications with DSCR1 and Heart Defects, Congenital |
| Necrosis Antibodies | >7 publications with DSCR1 and Necrosis |
Organs/Tissues associated with anti-DSCR1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Muscle Antibodies | >176 publications with DSCR1 and Muscle |
| Brain Antibodies | >47 publications with DSCR1 and Brain |
| Heart Antibodies | >42 publications with DSCR1 and Heart |
| Vascular Antibodies | >31 publications with DSCR1 and Vascular |
| Blood Antibodies | >18 publications with DSCR1 and Blood |
| Embryonic Tissue Antibodies | >9 publications with DSCR1 and Embryonic Tissue |
| Kidney Antibodies | >8 publications with DSCR1 and Kidney |
| Nerve Antibodies | >7 publications with DSCR1 and Nerve |
| Lung Antibodies | >6 publications with DSCR1 and Lung |
| Bone Antibodies | >6 publications with DSCR1 and Bone |