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> Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

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Cat# NB-64-54108-100ug

Size : 100ug

Brand : Neo Biotech

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Phone : +1 850 650 7790

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Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

(Synonyms: ORW1, ORW, HHT1, ENG, Endoglin, END, CD105) Copy Product Info

Synonyms: ORW1, ORW, HHT1, ENG, Endoglin, END, CD105

Catalog No. TMPK-00359 Copy Product Info
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
Other Forms of Endoglin/CD105 Protein, Human, Recombinant (His & Avi):
Endoglin Protein, Human, Recombinant (Trx & His)
Endoglin/CD105 Protein, Human, Recombinant (hFc)
Endoglin/CD105 Protein, Human, Recombinant (His)
Endoglin/CD105 Protein, Mouse, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Immobilized Human Endoglin, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-Endoglin Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA.
Description
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
Species
Human
Expression System
HEK293 Cells
TagC-His-Avi
Accession NumberP17813-1
ConstructionGlu26-Gly586
Protein Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsORW1, ORW, HHT1, ENG, Endoglin, END, CD105
Research Background
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
Chemical Properties
Molecular Weight63.7 kDa (predicted). Due to glycosylation, the protein migrates to 70-82 kDa based on Tris-Bis PAGE result.
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

ORW-1ORW 1HHT-1HHT 1CD-105CD 105
Related Tags: Endoglin/CD105 Protein, Human, Recombinant (His & Avi) chemical structure | Endoglin/CD105 Protein, Human, Recombinant (His & Avi) molecular weight