ER Blocking Peptide
Cat# MBS9620262-1mg
Size : 1mg
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
Er Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9620262Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details
Product Overview
Online Datasheet in PDFProduct Name
ER, Blocking Peptide
Full Product Name
ER Blocking Peptide
Product Gene Name
ER blocking peptide
Product Synonym Names
DKFZp686N23123; ER alpha; ER; ER-alpha; Era; ESR; ESR1; ESR1_HUMAN; ESRA; Estradiol receptor; Estrogen nuclear receptor alpha; Estrogen receptor 1; Estrogen receptor alpha 3*, 4, 5, 6, 7*/822 isoform; Estrogen receptor alpha; Estrogen receptor alpha delta 3*, 4, 5, 6, 7*, 8*/941 isoform; Estrogen receptor alpha delta 3*, 4, 5, 6, 7*/819 2 isoform; Estrogen receptor alpha delta 4 +49 isoform; Estrogen receptor alpha delta 4*, 5, 6, 7*/654 isoform; Estrogen receptor alpha delta 4*, 5, 6, 7, 8*/901 isoform; Estrogen receptor alpha E1 E2 1 2; Estrogen receptor alpha E1 N2 E2 1 2; Estrogen receptor; ESTRR; NR3A1; Nuclear receptor subfamily 3 group A member 1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
66,216 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (152011631..152424409). Location: 6q25.1
OMIM
133430
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for ER blocking peptide
Blocking/Control
Related Product Information for ER blocking peptide
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.
Other Notes
Small volumes of ER blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for ER purchase
MBS9620262 is a blocking peptide targeting ER.
Additional Details
NCBI/Uniprot data below describe general gene information for ER. It may not necessarily be applicable to this product.
NCBI Official Full Name
estrogen receptor
NCBI Official Synonym Full Names
estrogen receptor 1
NCBI Official Symbol
ESR1
NCBI Official Synonym Symbols
ER; ESR; Era; ESRA; NR3A1
UniProt Protein Name
Estrogen receptor
UniProt Synonym Protein Names
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Protein Family
ER degradation-enhancing alpha-mannosidase-like protein
UniProt Gene Name
ESR1
UniProt Synonym Gene Names
ESR; NR3A1; ER
UniProt Entry Name
ESR1_HUMAN
NCBI Protein Information
estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen
NCBI Summary for ER
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for ER
ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; plasma membrane; integral to membrane; nucleus
Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; uterus development; signal transduction; response to estradiol stimulus; regulation of apoptosis; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; male gonad development; androgen metabolic process; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; gene expression; positive regulation of transcription factor activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling
Disease: Breast Cancer; Migraine With Or Without Aura, Susceptibility To, 1; Myocardial Infarction, Susceptibility To; Estrogen Resistance
Show more Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; plasma membrane; integral to membrane; nucleus
Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; uterus development; signal transduction; response to estradiol stimulus; regulation of apoptosis; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; male gonad development; androgen metabolic process; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; gene expression; positive regulation of transcription factor activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling
Disease: Breast Cancer; Migraine With Or Without Aura, Susceptibility To, 1; Myocardial Infarction, Susceptibility To; Estrogen Resistance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with ER blocking peptide
| Reference Product | PubMed Publications |
|---|---|
| ESR2 blocking peptide | >235 publications with ER and ESR2 |
| JUN blocking peptide | >100 publications with ER and JUN |
| PGR blocking peptide | >89 publications with ER and PGR |
| ERBB2 blocking peptide | >45 publications with ER and ERBB2 |
| BRCA1 blocking peptide | >27 publications with ER and BRCA1 |
| MYC blocking peptide | >25 publications with ER and MYC |
| EGFR blocking peptide | >20 publications with ER and EGFR |
| CCND1 blocking peptide | >19 publications with ER and CCND1 |
| TP53 blocking peptide | >14 publications with ER and TP53 |
| SP1 blocking peptide | >11 publications with ER and SP1 |
Pathways associated with ER blocking peptide
| Products by Pathway | Pathway Diagram |
|---|---|
| Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies | Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram |
| Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies | Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram |
| Estrogen Signaling Pathway antibodies | Estrogen Signaling Pathway Diagram |
| Estrogen Signaling Pathway antibodies | Estrogen Signaling Pathway Diagram |
| Estrogen Signaling Pathway antibodies | Estrogen Signaling Pathway Diagram |
| FOXA1 Transcription Factor Network Pathway antibodies | FOXA1 Transcription Factor Network Pathway Diagram |
| FOXM1 Transcription Factor Network Pathway antibodies | FOXM1 Transcription Factor Network Pathway Diagram |
| Gene Expression Pathway antibodies | Gene Expression Pathway Diagram |
| Generic Transcription Pathway antibodies | Generic Transcription Pathway Diagram |
| Integrated Breast Cancer Pathway antibodies | Integrated Breast Cancer Pathway Diagram |
Diseases associated with ER blocking peptide
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >349 publications with ER and Neoplasms |
| Breast Neoplasms Antibodies | >220 publications with ER and Breast Neoplasms |
| Female Urogenital Diseases Antibodies | >87 publications with ER and Female Urogenital Diseases |
| Carcinoma Antibodies | >85 publications with ER and Carcinoma |
| Adenocarcinoma Antibodies | >43 publications with ER and Adenocarcinoma |
| Disease Progression Antibodies | >38 publications with ER and Disease Progression |
| Bone Diseases, Metabolic Antibodies | >35 publications with ER and Bone Diseases, Metabolic |
| Obesity Antibodies | >32 publications with ER and Obesity |
| Coronary Artery Disease Antibodies | >23 publications with ER and Coronary Artery Disease |
| Prostatic Neoplasms Antibodies | >22 publications with ER and Prostatic Neoplasms |
Organs/Tissues associated with ER blocking peptide
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >78 publications with ER and Brain |
| Uterus Antibodies | >60 publications with ER and Uterus |
| Ovary Antibodies | >52 publications with ER and Ovary |
| Heart Antibodies | >41 publications with ER and Heart |
| Testis Antibodies | >38 publications with ER and Testis |
| Prostate Antibodies | >33 publications with ER and Prostate |
| Muscle Antibodies | >28 publications with ER and Muscle |
| Connective Tissue Antibodies | >26 publications with ER and Connective Tissue |
| Lung Antibodies | >25 publications with ER and Lung |
| Lymph Node Antibodies | >17 publications with ER and Lymph Node |