Ercalcitriol [60133-18-8]
Cat# TQ0216-1mg
Size : 1mg
Brand : TargetMol
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Ercalcitriol
(Synonyms: 1α,25-Dihydroxy Vitamin D2) Copy Product Info
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections.
Cas No. 60133-18-8
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.02%
Appearance:Solid
Color:White
COA HNMR HPLC
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections. |
| In vivo | Ercalcitriol binds to vitamin D receptor (VDR), a nuclear receptor, activates the interaction between VDR and retinol X receptor (RXR) to form VDR/RXR/ cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription[3]. |
| Synonyms | 1α,25-Dihydroxy Vitamin D2 |
| Molecular Weight | 428.65 |
| Formula | C28H44O3 |
| Cas No. | 60133-18-8 |
| Smiles | C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |
| Relative Density. | 1.066 g/cm3 |
| Storage | Store at low temperature Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (104.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.67 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||