Ficolin-1, Human, mAb 7G1
Cat# MBS584675-0,1mg
Size : 0.1mg
Brand : MyBiosource
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Ficolin-1 (FCN1) Antibody – Mouse
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS584675The monoclonal antibody 7G1 recognizes human M-ficolin, also known as ficolin-1. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system,… More details
Product Overview
Online Datasheet in PDFProduct Name
Ficolin-1 (FCN1), Antibody
Full Product Name
Ficolin-1, Human, mAb 7G1
Product Gene Name
anti-FCN1 antibody
Product Synonym Names
M-ficolin, ficolin/P35-related
Isotype
IgG1
Host
Mouse
Form/Format
0.2 um filtered in PBS+0.1%BSA+0.02%NaN3
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
Purity/Purification
Protein G
Concentration
100 ug/ml (lot specific)
Preparation and Storage
Store at 4°C.
Applications Tested/Suitable for anti-FCN1 antibody
Flow Cytometry (FC), Immuno Assay (IA), Western Blot (WB)
Application Notes for anti-FCN1 antibody
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.
The typical starting working dilution is 1:50.
The typical starting working dilution is 1:50.
Product References and Citations for anti-FCN1 antibody
1. Wittenborn, T. et al; Characteristics and biological variations of M-Ficolin, a pattern recognition molecule, in plasma. J Innate Immun 2009, 2: 167 2. Schlappbach, L. et al; M-ficolin in the neonatal period: Associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis. Molecular Biology 2009, 46: 2597
Other Notes
Small volumes of anti-FCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for FCN1 purchase
MBS584675 is an antibody targeting FCN1. Also known as Ficolin-1, Human, mAb 7G1. Host: Mouse.
Additional Details
NCBI/Uniprot data below describe general gene information for FCN1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ficolin-1
NCBI Official Synonym Full Names
ficolin (collagen/fibrinogen domain containing) 1
NCBI Official Symbol
FCN1
NCBI Official Synonym Symbols
FCNM
UniProt Protein Name
Ficolin-1
UniProt Synonym Protein Names
Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin
Protein Family
Ficolin
UniProt Gene Name
FCN1
UniProt Synonym Gene Names
FCNM
UniProt Entry Name
FCN1_HUMAN
NCBI Protein Information
ficolin-1; M-ficolin; collagen/fibrinogen domain-containing protein 1; ficolin (collagen/fibrinogen domain-containing) 1; ficolin-A; ficolin-alpha
NCBI Summary for FCN1
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for FCN1
FCN1: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Belongs to the ficolin lectin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: collagen; extrinsic to external side of plasma membrane; extracellular region
Molecular Function: protein binding; G-protein-coupled receptor binding; metal ion binding; carbohydrate binding; pattern recognition receptor activity; sialic acid binding
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; complement activation
Show more Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: collagen; extrinsic to external side of plasma membrane; extracellular region
Molecular Function: protein binding; G-protein-coupled receptor binding; metal ion binding; carbohydrate binding; pattern recognition receptor activity; sialic acid binding
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; complement activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-FCN1 antibody
| Reference Product | PubMed Publications |
|---|---|
| MASP1 antibody | >2 publications with FCN1 and MASP1 |
| MASP2 antibody | >1 publications with FCN1 and MASP2 |
Pathways associated with anti-FCN1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Complement Cascade Pathway antibodies | Complement Cascade Pathway Diagram |
| Creation Of C4 And C2 Activators Pathway antibodies | Creation Of C4 And C2 Activators Pathway Diagram |
| Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies | Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram |
| Immune System Pathway antibodies | Immune System Pathway Diagram |
| Initial Triggering Of Complement Pathway antibodies | Initial Triggering Of Complement Pathway Diagram |
| Innate Immune System Pathway antibodies | Innate Immune System Pathway Diagram |
| Lectin Pathway Of Complement Activation antibodies | Lectin Pathway Of Complement Activation Diagram |
Diseases associated with anti-FCN1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >4 publications with FCN1 and Inflammation |
| Necrosis Antibodies | >1 publications with FCN1 and Necrosis |
Organs/Tissues associated with anti-FCN1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >12 publications with FCN1 and Blood |
| Kidney Antibodies | >1 publications with FCN1 and Kidney |
| Bone Antibodies | >1 publications with FCN1 and Bone |
| Brain Antibodies | >1 publications with FCN1 and Brain |
| Bone Marrow Antibodies | >1 publications with FCN1 and Bone Marrow |
| Intestine Antibodies | >1 publications with FCN1 and Intestine |
| Lung Antibodies | >1 publications with FCN1 and Lung |