Glutathione monoethyl ester

Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.|Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis.||Synonyms:|Ethyl gamma-glutamylcysteinylglycinate; Glutathione reduced ethyl ester|GSH-MEE; Glutathione Monoethyl Ester; gamma-Glu-Cys-Gly-OEt||CAS No:|118421-50-4||Molecular Formula:|C21H21N3O6S||Molecular Weight:|443.47||Appearance:|White to off-white powder||Purity:|≥98% (HPLC)||Solubility:|Water: 50mg/ml||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.