Hepoxilin A3 [94161-11-2]

Hepoxilin A3 (HXA3) is a neutrophil chemoattractant synthesized through the activation of the PLA2-12-LOX pathway. It directs neutrophils to migrate across epithelial barriers to sites of infection, such as the alveolar space. In mouse models, levels of Hepoxilin A3 rise in tandem with neutrophil infiltration. It is used in research on inflammatory diseases like pneumonia and cystic fibrosis.