Human Glucagon
Cat# MBS142679-10mg
Size : 10mg
Brand : MyBiosource
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Glucagon (GCG) Human Synthetic Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142679Glucagon Human Synthetic is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3483 Dalton and the molecular formula is: C153H225N43O49S.The Glucagon is purified by proprietary chromatographic techniques. More details
Product Overview
Product Name
Glucagon (GCG), Synthetic Protein
Full Product Name
Human Glucagon
Product Gene Name
GCG synthetic protein
Product Synonym Names
GLP1, GLP2, GRPP
Sequence
His-Ser-Gl n-Gly-Thr- Phe-Thr-Se r-Asp-Tyr- Ser-Lys-Ty r-Leu-Asp- Ser-Arg-Ar g-Ala-Gln- Asp-Phe-Va l-Gln-Trp- Leu-Met-As n-Thr-OH
Form/Format
Glucagon peptide was formulated with no additives.
Purity/Purification
Greater than 98.0% as determined by RP-HPLC.
Preparation and Storage
Glucagon although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Glucagon should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Molecular Weight
20,909 Da
OMIM
138030
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized Glucagon in a sterile 1% HCl solution at a concentration of 0.1-1 mg/ml, which can then be further diluted to other aqueous solutions.
Other Notes
Small volumes of GCG synthetic protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for GCG purchase
MBS142679 is a synthetic protein targeting GCG. Also known as Human Glucagon.
Additional Details
NCBI/Uniprot data below describe general gene information for GCG. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glucagon preproprotein
NCBI Official Synonym Full Names
glucagon
NCBI Official Symbol
GCG
NCBI Official Synonym Symbols
GLP1; GLP2; GRPP
UniProt Protein Name
Glucagon
UniProt Synonym Protein Names
Incretin hormone
Protein Family
Glucagon
UniProt Gene Name
GCG
UniProt Synonym Gene Names
GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2
UniProt Entry Name
GLUC_HUMAN
NCBI Protein Information
glucagon; glicentin-related polypeptide; glucagon-like peptide 1; glucagon-like peptide 2; preproglucagon
NCBI Summary for GCG
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for GCG
GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.
Protein type: Secreted; Hormone; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q36-q37
Cellular Component: extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding
Biological Process: response to starvation; G-protein signaling, coupled to cAMP nucleotide second messenger; cell proliferation; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; positive regulation of histone H3-K4 methylation; signal transduction; regulation of insulin secretion; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptosis
Show more Protein type: Secreted; Hormone; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q36-q37
Cellular Component: extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding
Biological Process: response to starvation; G-protein signaling, coupled to cAMP nucleotide second messenger; cell proliferation; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; positive regulation of histone H3-K4 methylation; signal transduction; regulation of insulin secretion; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with GCG synthetic protein
| Reference Product | PubMed Publications |
|---|---|
| INS synthetic protein | >13 publications with GCG and INS |
| GLP1R synthetic protein | >7 publications with GCG and GLP1R |
| SST synthetic protein | >5 publications with GCG and SST |
| GCGR synthetic protein | >5 publications with GCG and GCGR |
| GIPR synthetic protein | >2 publications with GCG and GIPR |
| SCT synthetic protein | >2 publications with GCG and SCT |
| FOXA2 synthetic protein | >2 publications with GCG and FOXA2 |
Pathways associated with GCG synthetic protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Class B/2 (Secretin Family Receptors) Pathway antibodies | Class B/2 (Secretin Family Receptors) Pathway Diagram |
| Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies | Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| FOXA1 Transcription Factor Network Pathway antibodies | FOXA1 Transcription Factor Network Pathway Diagram |
| G Alpha (q) Signalling Events Pathway antibodies | G Alpha (q) Signalling Events Pathway Diagram |
| G Alpha (s) Signalling Events Pathway antibodies | G Alpha (s) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies | Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram |
| Glucagon Signaling In Metabolic Regulation Pathway antibodies | Glucagon Signaling In Metabolic Regulation Pathway Diagram |
Diseases associated with GCG synthetic protein
| Disease Name | Pubmed Publications |
|---|---|
| Muscular Diseases Antibodies | >72 publications with GCG and Muscular Diseases |
| Diabetes Mellitus, Type 2 Antibodies | >25 publications with GCG and Diabetes Mellitus, Type 2 |
| Obesity Antibodies | >18 publications with GCG and Obesity |
| Vascular Diseases Antibodies | >15 publications with GCG and Vascular Diseases |
| Insulin Resistance Antibodies | >12 publications with GCG and Insulin Resistance |
| Hyperglycemia Antibodies | >11 publications with GCG and Hyperglycemia |
| Kidney Diseases Antibodies | >11 publications with GCG and Kidney Diseases |
| Hyperinsulinism Antibodies | >9 publications with GCG and Hyperinsulinism |
| Inflammation Antibodies | >8 publications with GCG and Inflammation |
| Heart Diseases Antibodies | >8 publications with GCG and Heart Diseases |
Organs/Tissues associated with GCG synthetic protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Pancreas Antibodies | >39 publications with GCG and Pancreas |
| Liver Antibodies | >20 publications with GCG and Liver |
| Intestine Antibodies | >19 publications with GCG and Intestine |
| Connective Tissue Antibodies | >13 publications with GCG and Connective Tissue |
| Stomach Antibodies | >7 publications with GCG and Stomach |
| Embryonic Tissue Antibodies | >6 publications with GCG and Embryonic Tissue |
| Uterus Antibodies | >1 publications with GCG and Uterus |
| Uncharacterized Tissue Antibodies | >1 publications with GCG and Uncharacterized Tissue |