Human Leptin
Cat# MBS691942-0,2mg
Size : 0.2mg
Brand : MyBiosource
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Leptin (LEP) Human Active Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691942Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body… More details
Product Overview
Online Datasheet in PDFProduct Name
Leptin, Active Protein
Full Product Name
Human Leptin
Product Gene Name
LEP active protein
Product Synonym Names
Recombinant Human Leptin
Sequence
MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGL HPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV L AFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDM LWQ LDLSPGC
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
95 % (SDS-PAGE, HPLC)
Molecular Weight
16.0 kDa
Chromosome Location
Chromosome: 7; NC_000007.14 (128241189..128257629). Location: 7q31.3
OMIM
164160
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ug of Leptin
Biological Activity
Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Product Categories/Family for LEP active protein
Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of LEP active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for LEP purchase
MBS691942 is an active protein targeting LEP. Also known as Human Leptin. Reactive in Human. Host: E Coli.
Additional Details
NCBI/Uniprot data below describe general gene information for LEP. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
leptin
NCBI Official Synonym Full Names
leptin
NCBI Official Symbol
LEP
NCBI Official Synonym Symbols
OB; OBS; LEPD
UniProt Protein Name
Leptin
UniProt Synonym Protein Names
Obese protein; Obesity factor
Protein Family
Ethylene-responsive transcription factor
UniProt Gene Name
LEP
UniProt Synonym Gene Names
OB; OBS
UniProt Entry Name
LEP_HUMAN
NCBI Protein Information
leptin; obese protein; obesity factor; obese, mouse, homolog of; leptin (murine obesity homolog); leptin (obesity homolog, mouse)
NCBI Summary for LEP
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for LEP
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subunit structure: Interacts with SIGLEC6. Ref.11
Subcellular location: Secreted.
Involvement in disease: Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16
Sequence similarities: Belongs to the leptin family.
Show more Subunit structure: Interacts with SIGLEC6. Ref.11
Subcellular location: Secreted.
Involvement in disease: Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16
Sequence similarities: Belongs to the leptin family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with LEP active protein
| Reference Product | PubMed Publications |
|---|---|
| LEPR active protein | >156 publications with LEP and LEPR |
| STAT3 active protein | >14 publications with LEP and STAT3 |
| INS active protein | >11 publications with LEP and INS |
| GHRL active protein | >11 publications with LEP and GHRL |
| CRP active protein | >6 publications with LEP and CRP |
| JAK2 active protein | >5 publications with LEP and JAK2 |
| PTPN1 active protein | >2 publications with LEP and PTPN1 |
| SOCS3 active protein | >1 publications with LEP and SOCS3 |
Pathways associated with LEP active protein
| Products by Pathway | Pathway Diagram |
|---|---|
| AMPK Signaling Pathway antibodies | AMPK Signaling Pathway Diagram |
| Adipocytokine Signaling Pathway antibodies | Adipocytokine Signaling Pathway Diagram |
| Adipocytokine Signaling Pathway antibodies | Adipocytokine Signaling Pathway Diagram |
| Adipogenesis Pathway antibodies | Adipogenesis Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| HIF-1-alpha Transcription Factor Network Pathway antibodies | HIF-1-alpha Transcription Factor Network Pathway Diagram |
| Incretin Synthesis, Secretion, And Inactivation Pathway antibodies | Incretin Synthesis, Secretion, And Inactivation Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
Diseases associated with LEP active protein
| Disease Name | Pubmed Publications |
|---|---|
| Obesity Antibodies | >317 publications with LEP and Obesity |
| Pain Antibodies | >160 publications with LEP and Pain |
| Insulin Resistance Antibodies | >105 publications with LEP and Insulin Resistance |
| Hyperinsulinism Antibodies | >67 publications with LEP and Hyperinsulinism |
| Weight Gain Antibodies | >54 publications with LEP and Weight Gain |
| Weight Loss Antibodies | >50 publications with LEP and Weight Loss |
| Cardiovascular Diseases Antibodies | >49 publications with LEP and Cardiovascular Diseases |
| Fatty Liver Antibodies | >39 publications with LEP and Fatty Liver |
| Inflammation Antibodies | >36 publications with LEP and Inflammation |
| Liver Diseases Antibodies | >32 publications with LEP and Liver Diseases |
Organs/Tissues associated with LEP active protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >337 publications with LEP and Blood |
| Adipose Tissue Antibodies | >156 publications with LEP and Adipose Tissue |
| Muscle Antibodies | >113 publications with LEP and Muscle |
| Connective Tissue Antibodies | >112 publications with LEP and Connective Tissue |
| Intestine Antibodies | >20 publications with LEP and Intestine |
| Placenta Antibodies | >16 publications with LEP and Placenta |
| Mouth Antibodies | >9 publications with LEP and Mouth |
| Mammary Gland Antibodies | >3 publications with LEP and Mammary Gland |
| Thymus Antibodies | >2 publications with LEP and Thymus |