IL10 (Human) ELISpot Kit

Quantification

Entrez GeneID

Gene Name

IL10

Gene Alias

CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF

Gene Description

interleukin 10

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq

Other Designations

cytokine synthesis inhibitory factor