Biovalley > Insr antibody - middle region
Insr antibody - middle region
Brand : Aviva Systems Biology
Insr Antibody - middle region (ARP41373_P050)
| Datasheets/Manuals | Printable datasheet for anti-Insr (ARP41373_P050) antibody |
|---|
| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide corresponding to a region of Mouse |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: EEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPY |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-Insr (ARP41373_P050) antibody is Catalog # AAP41373 (Previous Catalog # AAPP24111) |
| Gene Symbol | Insr |
|---|---|
| Gene Full Name | Insulin receptor |
| Alias Symbols | I, IR, IR-A, IR-B, CD220, 4932439J01Rik, D630014A15Rik |
| NCBI Gene Id | 16337 |
| Protein Name | Insulin receptor |
| Description of Target | This receptor binds insulin and has a tyrosine-protein kinase activity. When it is present in a hybrid receptor with IGF1R, binds IGF1. |
| Uniprot ID | P15208 |
| Protein Accession # | NP_034698 |
| Nucleotide Accession # | NM_010568 |
| Protein Size (# AA) | 1372 |
| Molecular Weight | 155kDa |
| Protein Interactions | Arrb2; Src; Akt1; Jup; Irs1; Grb10; Snx9; Dok3; Sh2b2; Flot1; Dok1; Cav3; Socs1; Socs3; Sorbs1; Cav1; Pik3r1; |
Protein interactions
| Name | # of Products |
|---|---|
| Pik3r1 | 517 |
Biological pathways
| Name | # of Products |
|---|---|
| Cellular response to growth factor stimulus | 27 |
| Exocrine pancreas development | 14 |
| Male sex determination | 6 |
| Organ morphogenesis | 186 |
| Positive regulation of glycogen biosynthetic process | 109 |
| Protein autophosphorylation | 356 |
| Protein heterotetramerization | 10 |
Biological process
| Name | # of Products |
|---|---|
| Activation of MAPK activity | 105 |
| Activation of protein kinase activity | 27 |
| Activation of protein kinase B activity | 12 |
| Cellular response to growth factor stimulus | 63 |
| Cellular response to insulin stimulus | 69 |
| Exocrine pancreas development | 16 |
| Glucose homeostasis | 77 |
| G-protein coupled receptor signaling pathway | 262 |
| Heart morphogenesis | 47 |
| Insulin receptor signaling pathway | 146 |
| Male sex determination | 12 |
| Negative regulation of gene expression | 70 |
| Negative regulation of protein phosphorylation | 40 |
| Negative regulation of transporter activity | 8 |
| Organ morphogenesis | 132 |
| Peptidyl-tyrosine phosphorylation | 72 |
| Phosphorylation | 101 |
| Positive regulation of cell migration | 150 |
| Positive regulation of cell proliferation | 483 |
| Positive regulation of developmental growth | 7 |
| Positive regulation of DNA replication | 56 |
| Positive regulation of glucose import | 34 |
| Positive regulation of glycogen biosynthetic process | 23 |
| Positive regulation of glycolysis | 15 |
| Positive regulation of glycoprotein biosynthetic process | 7 |
| Positive regulation of MAPK cascade | 81 |
| Positive regulation of mitosis | 50 |
| Positive regulation of nitric oxide biosynthetic process | 53 |
| Positive regulation of phosphorylation | 34 |
| Positive regulation of protein kinase B signaling cascade | 61 |
| Positive regulation of protein phosphorylation | 125 |
| Positive regulation of respiratory burst | 5 |
| Protein autophosphorylation | 150 |
| Protein heterotetramerization | 9 |
| Protein phosphorylation | 451 |
| Regulation of embryonic development | 10 |
| Regulation of hydrogen peroxide metabolic process | 7 |
| Regulation of transcription, DNA-dependent | 1734 |
| Response to tumor necrosis factor | 32 |
| Signal transduction by phosphorylation | 12 |
| Transformation of host cell by virus | 4 |
| Transmembrane receptor protein tyrosine kinase signaling pathway | 67 |
Cellular components
| Name | # of Products |
|---|---|
| Caveola | 62 |
| Cytosol | 1868 |
| Endosome | 258 |
| Insulin receptor complex | 4 |
| Integral to membrane | 2793 |
| Integral to plasma membrane | 817 |
| Membrane | 2769 |
| Microsome | 250 |
| Nucleus | 4914 |
| Plasma membrane | 2678 |
| Soluble fraction | 338 |
| Synapse | 236 |
Protein function
| Name | # of Products |
|---|---|
| 3-phosphoinositide-dependent protein kinase binding | 12 |
| ATP binding | 2814 |
| GTP binding | 556 |
| Insulin binding | 37 |
| Insulin receptor substrate binding | 51 |
| Insulin-activated receptor activity | 10 |
| Insulin-like growth factor I binding | 47 |
| Insulin-like growth factor II binding | 13 |
| Insulin-like growth factor receptor binding | 112 |
| Kinase activity | 353 |
| Lipoic acid binding | 10 |
| Nucleotide binding | 3928 |
| Phosphatidylinositol 3-kinase binding | 81 |
| Protein binding | 12191 |
| Protein complex binding | 333 |
| Protein domain specific binding | 530 |
| Protein kinase activity | 636 |
| Protein kinase binding | 1101 |
| Protein phosphatase binding | 147 |
| Protein tyrosine kinase activity | 369 |
| PTB domain binding | 27 |
| Receptor activity | 3624 |
| Receptor signaling protein tyrosine kinase activity | 83 |
| SH2 domain binding | 94 |
| Transferase activity | 1042 |
| Transferase activity, transferring phosphorus-containing groups | 127 |
| Transmembrane receptor protein tyrosine kinase activity | 157 |
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