LPHN1 Antibody
Cat# MBS8582088-0,1mL-FITC
Size : 0.1mL(FITC)
Brand : MyBiosource
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Phone : +1 850 650 7790
LPHN1 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582088MBS8582088 is an antibody targeting LPHN1. Also known as LPHN1 Antibody. Reactive in Human, Mouse, Rat, Bovine. Host: Rabbit. Rabbit polyclonal antibody to LPHN1 More details
Product Overview
Online Datasheet in PDFProduct Name
LPHN1, Polyclonal Antibody
Full Product Name
LPHN1 Antibody
Product Gene Name
anti-LPHN1 antibody
Product Synonym Names
KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of LPHN1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
162,717 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (14258549..14316997, complement). Location: 19p13.2
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LPHN1. The exact sequence is proprietary.
Product Categories/Family for anti-LPHN1 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LPHN1 antibody
Western Blot (WB)
Application Notes for anti-LPHN1 antibody
WB: 1:500-1:1000
Other Notes
Small volumes of anti-LPHN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for LPHN1. It may not necessarily be applicable to this product.
NCBI Official Full Name
latrophilin-1 isoform 1
NCBI Official Synonym Full Names
latrophilin 1
NCBI Official Symbol
LPHN1
NCBI Official Synonym Symbols
CL1; LEC2; CIRL1
UniProt Protein Name
Latrophilin-1
UniProt Synonym Protein Names
Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2
UniProt Gene Name
LPHN1
UniProt Synonym Gene Names
KIAA0821; LEC2; CIRL-1
UniProt Entry Name
LPHN1_HUMAN
NCBI Protein Information
latrophilin-1; CIRL-1; lectomedin-2; calcium-independent alpha-latrotoxin receptor 1
NCBI Summary for LPHN1
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Show more UniProt Comments for LPHN1
latrophilin 1: Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: presynaptic membrane; neuron projection; growth cone; axon; integral to membrane; plasma membrane; synapse; cell junction
Molecular Function: G-protein coupled receptor activity; protein binding; latrotoxin receptor activity; cell adhesion molecule binding; carbohydrate binding
Biological Process: heterophilic cell adhesion; G-protein coupled receptor protein signaling pathway
Show more Protein type: Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: presynaptic membrane; neuron projection; growth cone; axon; integral to membrane; plasma membrane; synapse; cell junction
Molecular Function: G-protein coupled receptor activity; protein binding; latrotoxin receptor activity; cell adhesion molecule binding; carbohydrate binding
Biological Process: heterophilic cell adhesion; G-protein coupled receptor protein signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-LPHN1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| GPCRs, Class B Secretin-like Pathway antibodies | GPCRs, Class B Secretin-like Pathway Diagram |
Diseases associated with anti-LPHN1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Lung Neoplasms Antibodies | >1 publications with LPHN1 and Lung Neoplasms |
| Neoplasms Antibodies | >1 publications with LPHN1 and Neoplasms |
| Cardiovascular Diseases Antibodies | >1 publications with LPHN1 and Cardiovascular Diseases |
| Brain Diseases Antibodies | >1 publications with LPHN1 and Brain Diseases |
| Nervous System Diseases Antibodies | >1 publications with LPHN1 and Nervous System Diseases |
| Neoplasms, Experimental Antibodies | >1 publications with LPHN1 and Neoplasms, Experimental |
| Kidney Diseases Antibodies | >1 publications with LPHN1 and Kidney Diseases |
| Disease Models, Animal Antibodies | >1 publications with LPHN1 and Disease Models, Animal |
Organs/Tissues associated with anti-LPHN1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >3 publications with LPHN1 and Brain |
| Nerve Antibodies | >2 publications with LPHN1 and Nerve |
| Kidney Antibodies | >1 publications with LPHN1 and Kidney |
| Lung Antibodies | >1 publications with LPHN1 and Lung |
| Eye Antibodies | >1 publications with LPHN1 and Eye |