Macrophage Inflammatory Protein 3, Human (MIP-3) (Biotin)
Cat# MBS624290-0,025mg
Size : 0.025mg
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
Macrophage Inflammatory Protein 3 (CCL19) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624290MBS624290 is an antibody targeting CCL19. Also known as Macrophage Inflammatory Protein 3, Human (MIP-3) (Biotin). Reactive in Human. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Macrophage Inflammatory Protein 3 (CCL19), Polyclonal Antibody
Full Product Name
Macrophage Inflammatory Protein 3, Human (MIP-3) (Biotin)
Product Gene Name
anti-CCL19 antibody
Product Synonym Names
Anti -Macrophage Inflammatory Protein 3, Human (MIP-3) (Biotin)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Sterile-filtered antibody solution lyophilized from 0.5X PBS, pH 7.4. Conjugated with biotin.
Purity/Purification
Highly Purified
Purified by antigen affinity chromatography
Purified by antigen affinity chromatography
Specificity
Recognizes Human MIP-3
Preparation and Storage
-20 degree C
Molecular Weight
10,993 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (34689567..34691274, complement). Location: 9p13
OMIM
602227
Immunogen
Highly purified human MIP-3
Product Categories/Family for anti-CCL19 antibody
Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-CCL19 antibody
ELISA (EL/EIA), Western Blot (WB), Neutralization
Application Notes for anti-CCL19 antibody
Suitable for use in Neutralization, ELISA, Western Blotting.
ELISA: To detect hMIP-3 by direct ELISA (using 100ul/well antibody solution) this antibody can be used at a concentration of 0.15-0.30ug/ml. Used in conjunction with compatible secondary reagents, allows the detection of at least 0.2ng/well of recombinant hMIP-3.
Western Blot: To detect hMIP-3 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMIP-3 is 1.5-3.0ng/lane, under either reducing or non-reducing conditions.
Reconstitute to a concentration of 50ug/ml with sterile PBS solution containing 0.1% BSA. This solution can be stored at 4 degree C for at least one month without detectable loss of activity. Frozen aliquots of this solution are stable for at least 6 months when kept at -20 degree C. Avoid more than one freeze-thaw cycle.
ELISA: To detect hMIP-3 by direct ELISA (using 100ul/well antibody solution) this antibody can be used at a concentration of 0.15-0.30ug/ml. Used in conjunction with compatible secondary reagents, allows the detection of at least 0.2ng/well of recombinant hMIP-3.
Western Blot: To detect hMIP-3 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMIP-3 is 1.5-3.0ng/lane, under either reducing or non-reducing conditions.
Reconstitute to a concentration of 50ug/ml with sterile PBS solution containing 0.1% BSA. This solution can be stored at 4 degree C for at least one month without detectable loss of activity. Frozen aliquots of this solution are stable for at least 6 months when kept at -20 degree C. Avoid more than one freeze-thaw cycle.
Other Notes
Small volumes of anti-CCL19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CCL19. It may not necessarily be applicable to this product.
NCBI Official Full Name
macrophage inflammatory protein 3 beta
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 19
NCBI Official Symbol
CCL19
NCBI Official Synonym Symbols
ELC; CKb11; MIP3B; MIP-3b; SCYA19
UniProt Protein Name
C-C motif chemokine 19
UniProt Synonym Protein Names
Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Macrophage inflammatory protein 3 beta; MIP-3-beta; Small-inducible cytokine A19
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL19
UniProt Synonym Gene Names
ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta
UniProt Entry Name
CCL19_HUMAN
NCBI Protein Information
C-C motif chemokine 19; exodus-3; CK beta-11; MIP-3-beta; EBI1 ligand chemokine; EBI1-ligand chemokine; CC chemokine ligand 19; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19
NCBI Summary for CCL19
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for CCL19
CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: extracellular space; extracellular region
Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding
Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; establishment of T cell polarity; positive regulation of T cell proliferation; cell communication; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation
Show more Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: extracellular space; extracellular region
Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding
Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; establishment of T cell polarity; positive regulation of T cell proliferation; cell communication; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CCL19 antibody
| Reference Product | PubMed Publications |
|---|---|
| CCR7 antibody | >394 publications with CCL19 and CCR7 |
| CXCL13 antibody | >91 publications with CCL19 and CXCL13 |
| CXCL10 antibody | >46 publications with CCL19 and CXCL10 |
| CCR5 antibody | >46 publications with CCL19 and CCR5 |
| CCR6 antibody | >45 publications with CCL19 and CCR6 |
| CXCL9 antibody | >34 publications with CCL19 and CXCL9 |
| CXCR5 antibody | >30 publications with CCL19 and CXCR5 |
| CCL25 antibody | >24 publications with CCL19 and CCL25 |
| CCR1 antibody | >22 publications with CCL19 and CCR1 |
| CXCL11 antibody | >19 publications with CCL19 and CXCL11 |
Pathways associated with anti-CCL19 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Chemokine Receptors Bind Chemokines Pathway antibodies | Chemokine Receptors Bind Chemokines Pathway Diagram |
| Chemokine Signaling Pathway antibodies | Chemokine Signaling Pathway Diagram |
| Chemokine Signaling Pathway antibodies | Chemokine Signaling Pathway Diagram |
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| NF-kappa B Signaling Pathway antibodies | NF-kappa B Signaling Pathway Diagram |
Diseases associated with anti-CCL19 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >134 publications with CCL19 and Inflammation |
| Immune System Diseases Antibodies | >124 publications with CCL19 and Immune System Diseases |
| Neoplasms Antibodies | >104 publications with CCL19 and Neoplasms |
| Necrosis Antibodies | >61 publications with CCL19 and Necrosis |
| Nervous System Diseases Antibodies | >38 publications with CCL19 and Nervous System Diseases |
| Lung Diseases Antibodies | >37 publications with CCL19 and Lung Diseases |
| Vascular Diseases Antibodies | >26 publications with CCL19 and Vascular Diseases |
| Hypersensitivity Antibodies | >26 publications with CCL19 and Hypersensitivity |
| Carcinoma, Squamous Cell Antibodies | >17 publications with CCL19 and Carcinoma, Squamous Cell |
| Liver Diseases Antibodies | >13 publications with CCL19 and Liver Diseases |
Organs/Tissues associated with anti-CCL19 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Lymph Node Antibodies | >258 publications with CCL19 and Lymph Node |
| Vascular Antibodies | >76 publications with CCL19 and Vascular |
| Spleen Antibodies | >66 publications with CCL19 and Spleen |
| Lung Antibodies | >55 publications with CCL19 and Lung |
| Thymus Antibodies | >33 publications with CCL19 and Thymus |
| Brain Antibodies | >25 publications with CCL19 and Brain |
| Intestine Antibodies | >19 publications with CCL19 and Intestine |
| Eye Antibodies | >18 publications with CCL19 and Eye |
| Pancreas Antibodies | >16 publications with CCL19 and Pancreas |
| Heart Antibodies | >12 publications with CCL19 and Heart |