Mouse Anti-Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) - With BSA and Azide Monoclonal Antibody
Cat# AH12566-U0100
Size : 100ug
Brand : Abcepta
Contact local distributor :
Phone : +1 850 650 7790
Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone CALD1/820 + h-CALD ]
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Formalin-fixed, paraffin-embedded human Uterus stained with Caldesmon Monoclonal Antibody (CALD1/820 + h-CALD).
Formalin-fixed, paraffin-embedded human Uterus stained with Caldesmon Monoclonal Antibody (CALD1/820 + h-CALD).
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | Q05682 |
| Other Accession | 800, 490203 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG's |
| Clone Names | CALD1/820 + h-CALD |
| Calculated MW | 150kDa |
| Gene ID | 800 |
|---|---|
| Other Names | Caldesmon, CDM, CALD1, CAD, CDM |
| Application Note | IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CALD1 |
|---|---|
| Synonyms | CAD, CDM |
| Function | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P13505}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:P13505}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P13505}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) {ECO:0000250|UniProtKB:P13505} |
| Tissue Location | High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart |
Research Areas
- Primary Antibodies
- Cardiovascular
- Signal Transduction
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