Mouse Kininogen genetically deficient plasma, sodium citrate
Cat# MBS136143-0,05mL
Size : 0.05mL
Brand : MyBiosource
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Phone : +1 850 650 7790
KNG1 Plasma – Kininogen Genetically Deficient Plasma, Sodium Citrate
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS136143This plasma is an ideal negative control for ELISA based assays and other experiments involving kininogen. Collected from homozygous kininogen knockout mice, anticoagulated with sodium citrate and flash frozen. Collected from male mice. Female mouse plasma is… More details
Product Overview
Online Datasheet in PDFProduct Name
Kininogen genetically deficient plasma, sodium citrate (KNG1), Plasma
Full Product Name
Mouse Kininogen genetically deficient plasma, sodium citrate
Product Gene Name
KNG1 plasma
Host
Kininogen knockout mouse
Form/Format
Frozen liquid
Purity/Purification
Plasma
Preparation and Storage
Store at -70 degree C
Expiration: 3 years from delivery
Shipping: Dry Ice
Expiration: 3 years from delivery
Shipping: Dry Ice
Other Notes
Small volumes of KNG1 plasma vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for KNG1 purchase
MBS136143 is a plasma targeting KNG1. Also known as Mouse Kininogen genetically deficient plasma, sodium citrate. Host: Kininogen knockout mouse.
Additional Details
NCBI/Uniprot data below describe general gene information for KNG1. It may not necessarily be applicable to this product.
NCBI Official Full Name
high molecular weight kininogen I isoform DeltaD5
NCBI Official Synonym Full Names
kininogen 1
NCBI Official Symbol
Kng1
NCBI Official Synonym Symbols
Kng
UniProt Protein Name
Kininogen-1
Protein Family
Kininogen
UniProt Gene Name
Kng1
UniProt Synonym Gene Names
Kng
UniProt Entry Name
KNG1_MOUSE
NCBI Protein Information
kininogen-1
UniProt Comments for KNG1
KNG1: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency). HMWK deficiency is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Contractile; Cell adhesion; Secreted, signal peptide; Inhibitor; Secreted; Motility/polarity/chemotaxis
Cellular Component: extracellular space; extracellular region
Molecular Function: protease inhibitor activity; cysteine protease inhibitor activity; receptor binding
Biological Process: hemostasis; negative regulation of peptidase activity; regulation of blood vessel size; blood coagulation; inflammatory response; vasodilation
Show more Protein type: Contractile; Cell adhesion; Secreted, signal peptide; Inhibitor; Secreted; Motility/polarity/chemotaxis
Cellular Component: extracellular space; extracellular region
Molecular Function: protease inhibitor activity; cysteine protease inhibitor activity; receptor binding
Biological Process: hemostasis; negative regulation of peptidase activity; regulation of blood vessel size; blood coagulation; inflammatory response; vasodilation
Research Articles on KNG1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with KNG1 plasma
| Products by Pathway | Pathway Diagram |
|---|---|
| ACE Inhibitor Pathway antibodies | ACE Inhibitor Pathway Diagram |
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies | Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| G Alpha (q) Signalling Events Pathway antibodies | G Alpha (q) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
Diseases associated with KNG1 plasma
| Disease Name | Pubmed Publications |
|---|---|
| Cardiovascular Diseases Antibodies | >9 publications with KNG1 and Cardiovascular Diseases |
| Heart Diseases Antibodies | >5 publications with KNG1 and Heart Diseases |
| Thrombosis Antibodies | >4 publications with KNG1 and Thrombosis |
| Atherosclerosis Antibodies | >2 publications with KNG1 and Atherosclerosis |
| Carcinoma, Hepatocellular Antibodies | >2 publications with KNG1 and Carcinoma, Hepatocellular |
| Seizures Antibodies | >1 publications with KNG1 and Seizures |
| Neoplasms Antibodies | >1 publications with KNG1 and Neoplasms |
| Liver Diseases Antibodies | >1 publications with KNG1 and Liver Diseases |
| Kidney Diseases Antibodies | >1 publications with KNG1 and Kidney Diseases |
| Hypertension Antibodies | >1 publications with KNG1 and Hypertension |
Organs/Tissues associated with KNG1 plasma
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >2 publications with KNG1 and Liver |
| Eye Antibodies | >1 publications with KNG1 and Eye |
| Muscle Antibodies | >1 publications with KNG1 and Muscle |