Mouse sCD163 ELISA Kit
Cat# MBS2602526-96
Size : 96-Strip-Wells
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
Scd163 ELISA Kit for Mouse
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2602526Principle of the Assay: As mentioned above, this kit utilizes the Double Antibody Sandwich ELISA technique. The pre-coated antibody is an anti-Mouse sCD163 monoclonal antibody, while the detection antibody is a biotinylated polyclonal antibody. Samples and… More details
Product Overview
Online Datasheet in PDFProduct Name
sCD163, ELISA Kit
Full Product Name
Mouse sCD163 ELISA Kit
Product Gene Name
sCD163 elisa kit
Species Reactivity
Mouse
Assay Type
Quantitative Sandwich
Samples
Mouse serum, plasma or cell culture supernatant
Detection Range
10 ng/mL-0.156 ng/mL
Sensitivity
Up to 0.05 ng/mL
Preparation and Storage
Store all reagents at 2-8 degree C.
Inter-assay Precision
<= 12%
Intra-assay Precision
<= 8%
Molecular Weight
124,958 Da
OMIM
605545
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of sCD163 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for sCD163 purchase
MBS2602526 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sCD163, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing sCD163. The ELISA analytical biochemical technique of the MBS2602526 kit is based on sCD163 antibody-sCD163 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect sCD163 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, sCD163. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Additional Details
NCBI/Uniprot data below describe general gene information for sCD163. It may not necessarily be applicable to this product.
NCBI Official Full Name
scavenger receptor cysteine-rich type 1 protein M130 isoform a
NCBI Official Synonym Full Names
CD163 molecule
NCBI Official Symbol
CD163
NCBI Official Synonym Symbols
M130; MM130
UniProt Protein Name
Scavenger receptor cysteine-rich type 1 protein M130
UniProt Synonym Protein Names
Hemoglobin scavenger receptor; CD_antigen: CD163Cleaved into the following chain:Soluble CD163; sCD163
UniProt Gene Name
CD163
UniProt Synonym Gene Names
M130; sCD163
UniProt Entry Name
C163A_HUMAN
NCBI Protein Information
scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen
NCBI Summary for sCD163
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Show more UniProt Comments for sCD163
CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: protein binding; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; acute-phase response
Show more Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: protein binding; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; acute-phase response
Research Articles on sCD163
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with sCD163 elisa kit
| Reference Product | PubMed Publications |
|---|---|
| CD68 elisa kit | >366 publications with sCD163 and CD68 |
| IL10 elisa kit | >94 publications with sCD163 and IL10 |
| HMOX1 elisa kit | >43 publications with sCD163 and HMOX1 |
| CSF1R elisa kit | >29 publications with sCD163 and CSF1R |
| IL6 elisa kit | >13 publications with sCD163 and IL6 |
| C1QB elisa kit | >1 publications with sCD163 and C1QB |
| VSIG4 elisa kit | >1 publications with sCD163 and VSIG4 |
Pathways associated with sCD163 elisa kit
| Products by Pathway | Pathway Diagram |
|---|---|
| Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies | Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram |
| Scavenging Of Heme From Plasma Pathway antibodies | Scavenging Of Heme From Plasma Pathway Diagram |
Diseases associated with sCD163 elisa kit
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >362 publications with sCD163 and Inflammation |
| Necrosis Antibodies | >162 publications with sCD163 and Necrosis |
| Nervous System Diseases Antibodies | >104 publications with sCD163 and Nervous System Diseases |
| Brain Diseases Antibodies | >64 publications with sCD163 and Brain Diseases |
| Fibrosis Antibodies | >56 publications with sCD163 and Fibrosis |
| Lung Diseases Antibodies | >49 publications with sCD163 and Lung Diseases |
| Adenocarcinoma Antibodies | >40 publications with sCD163 and Adenocarcinoma |
| Heart Diseases Antibodies | >29 publications with sCD163 and Heart Diseases |
| Kidney Diseases Antibodies | >27 publications with sCD163 and Kidney Diseases |
| Neoplasms, Experimental Antibodies | >25 publications with sCD163 and Neoplasms, Experimental |
Organs/Tissues associated with sCD163 elisa kit
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >601 publications with sCD163 and Blood |
| Vascular Antibodies | >167 publications with sCD163 and Vascular |
| Skin Antibodies | >110 publications with sCD163 and Skin |
| Bone Antibodies | >102 publications with sCD163 and Bone |
| Liver Antibodies | >101 publications with sCD163 and Liver |
| Lung Antibodies | >72 publications with sCD163 and Lung |
| Brain Antibodies | >71 publications with sCD163 and Brain |
| Connective Tissue Antibodies | >46 publications with sCD163 and Connective Tissue |
| Heart Antibodies | >40 publications with sCD163 and Heart |
| Kidney Antibodies | >40 publications with sCD163 and Kidney |
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