Mouse Sirt6 activation kit by CRISPRa
CAT#: GA205336
Sirt6 CRISPRa kit - CRISPR gene activation of mouse sirtuin 6
Find the corresponding CRISPRi Inhibitor Kit
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Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
| Symbol | Sirt6 |
| Locus ID | 50721 |
| Kit Components | GA205336G1, Sirt6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205336G2, Sirt6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205336G3, Sirt6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001163430, NM_181586 |
| UniProt ID | P59941 |
| Synonyms | 2810449N18Rik; AI043036; Sir2l6 |
| Summary | NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice, but not in female mice.[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN315806 | Sirt6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN315806BN | Sirt6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN315806LP | Sirt6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN315806RB | Sirt6 - mouse gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN515806 | Sirt6 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR |