Nephrin Polyclonal Antibody PE-Cy7 Conjugated
Cat# MBS9462450-5x0,1mL
Size : 5x0.1mL
Brand : MyBiosource
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NEPHRIN Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9462450MBS9462450 is an antibody targeting Nephrin. Also known as Nephrin Polyclonal Antibody PE-Cy7 Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Nephrin, Polyclonal Antibody
Full Product Name
Nephrin Polyclonal Antibody PE-Cy7 Conjugated
Product Gene Name
anti-Nephrin antibody
Product Synonym Names
Nephrin
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purity/Purification
affinity purified by Protein A
Preparation and Storage
Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Applications Tested/Suitable for anti-Nephrin antibody
Flow Cytometry (FC)
Application Notes for anti-Nephrin antibody
FC: 1:50-200
Other Notes
Small volumes of anti-Nephrin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for Nephrin. It may not necessarily be applicable to this product.
NCBI Official Full Name
nephrin
NCBI Official Synonym Full Names
nephrosis 1, congenital, Finnish type (nephrin)
NCBI Official Symbol
NPHS1
NCBI Official Synonym Symbols
CNF; NPHN; nephrin
UniProt Protein Name
Nephrin
UniProt Synonym Protein Names
Renal glomerulus-specific cell adhesion receptor
Protein Family
Nephrin
UniProt Gene Name
NPHS1
UniProt Synonym Gene Names
NPHN
UniProt Entry Name
NPHN_HUMAN
NCBI Protein Information
nephrin; renal glomerulus-specific cell adhesion receptor
NCBI Summary for Nephrin
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]
Show more UniProt Comments for Nephrin
NPHS1: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1. Interacts with NPHS2. Specifically expressed in podocytes of kidney glomeruli. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: cell projection; protein complex; integral to plasma membrane; plasma membrane; lipid raft
Molecular Function: protein domain specific binding; protein binding; myosin binding; spectrin binding; alpha-actinin binding
Biological Process: skeletal muscle development; positive regulation of actin filament polymerization; glomerular basement membrane development; JNK cascade; excretion; cell adhesion; myoblast fusion
Disease: Nephrotic Syndrome, Type 1
Show more Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: cell projection; protein complex; integral to plasma membrane; plasma membrane; lipid raft
Molecular Function: protein domain specific binding; protein binding; myosin binding; spectrin binding; alpha-actinin binding
Biological Process: skeletal muscle development; positive regulation of actin filament polymerization; glomerular basement membrane development; JNK cascade; excretion; cell adhesion; myoblast fusion
Disease: Nephrotic Syndrome, Type 1
Research Articles on Nephrin
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-Nephrin antibody
| Reference Product | PubMed Publications |
|---|---|
| NPHS2 antibody | >66 publications with Nephrin and NPHS2 |
| CD2AP antibody | >22 publications with Nephrin and CD2AP |
| TJP1 antibody | >6 publications with Nephrin and TJP1 |
| TRPC6 antibody | >6 publications with Nephrin and TRPC6 |
| SRC antibody | >4 publications with Nephrin and SRC |
| KIRREL antibody | >4 publications with Nephrin and KIRREL |
| FYN antibody | >1 publications with Nephrin and FYN |
Pathways associated with anti-Nephrin antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Cell-Cell Communication Pathway antibodies | Cell-Cell Communication Pathway Diagram |
| Nephrin Interactions Pathway antibodies | Nephrin Interactions Pathway Diagram |
| Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway antibodies | Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway Diagram |
Diseases associated with anti-Nephrin antibody
| Disease Name | Pubmed Publications |
|---|---|
| Kidney Diseases Antibodies | >124 publications with Nephrin and Kidney Diseases |
| Nephrosis Antibodies | >97 publications with Nephrin and Nephrosis |
| Proteinuria Antibodies | >71 publications with Nephrin and Proteinuria |
| Glomerulonephritis Antibodies | >33 publications with Nephrin and Glomerulonephritis |
| Glomerulosclerosis, Focal Segmental Antibodies | >30 publications with Nephrin and Glomerulosclerosis, Focal Segmental |
| Renal Insufficiency Antibodies | >14 publications with Nephrin and Renal Insufficiency |
| Kidney Failure, Chronic Antibodies | >13 publications with Nephrin and Kidney Failure, Chronic |
| Hypertension Antibodies | >8 publications with Nephrin and Hypertension |
| Albuminuria Antibodies | >6 publications with Nephrin and Albuminuria |
| Fibrosis Antibodies | >5 publications with Nephrin and Fibrosis |
Organs/Tissues associated with anti-Nephrin antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Kidney Antibodies | >118 publications with Nephrin and Kidney |
| Pancreas Antibodies | >8 publications with Nephrin and Pancreas |
| Brain Antibodies | >6 publications with Nephrin and Brain |
| Thymus Antibodies | >3 publications with Nephrin and Thymus |
| Testis Antibodies | >2 publications with Nephrin and Testis |