NGK Antibody
Cat# MBS8583802-0,1mL-FITC
Size : 0.1mL(FITC)
Brand : MyBiosource
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Phone : +1 850 650 7790
NGK Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8583802MBS8583802 is an antibody targeting NGK. Also known as NGK Antibody. Reactive in Human, Mouse, Rat, Bovine, Dog, Pig. Host: Rabbit. Rabbit polyclonal antibody to NGK More details
Product Overview
Online Datasheet in PDFProduct Name
NGK, Polyclonal Antibody
Full Product Name
NGK Antibody
Product Gene Name
anti-NGK antibody
Product Synonym Gene Name
MAP4K4
Product Synonym Names
HGK; KIAA0687; NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of NGK protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
142,101 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (102314165..102511152). Location: 2q11.2-q12
OMIM
604666
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NGK. The exact sequence is proprietary.
Product Categories/Family for anti-NGK antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NGK antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-NGK antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-NGK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for NGK. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4 isoform 4
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase kinase 4
NCBI Official Symbol
MAP4K4
NCBI Official Synonym Symbols
HGK; NIK; MEKKK4; FLH21957
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase kinase 4
UniProt Synonym Protein Names
HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase
UniProt Gene Name
MAP4K4
UniProt Synonym Gene Names
HGK; KIAA0687; NIK; MEK kinase kinase 4; MEKKK 4
UniProt Entry Name
M4K4_HUMAN
NCBI Protein Information
mitogen-activated protein kinase kinase kinase kinase 4; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; Ste20 group protein kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like k
NCBI Summary for NGK
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for NGK
HGK: a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily
Chromosomal Location of Human Ortholog: 2q11.2-q12
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: microvillus biogenesis; regulation of catalytic activity; regulation of JNK cascade; protein amino acid phosphorylation
Show more Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily
Chromosomal Location of Human Ortholog: 2q11.2-q12
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: microvillus biogenesis; regulation of catalytic activity; regulation of JNK cascade; protein amino acid phosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-NGK antibody
| Reference Product | PubMed Publications |
|---|---|
| RAP2A antibody | >1 publications with NGK and RAP2A |
| GBP3 antibody | >1 publications with NGK and GBP3 |
Pathways associated with anti-NGK antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Ceramide Signaling Pathway antibodies | Ceramide Signaling Pathway Diagram |
| Direct P53 Effectors Pathway antibodies | Direct P53 Effectors Pathway Diagram |
| EPHB Forward Signaling Pathway antibodies | EPHB Forward Signaling Pathway Diagram |
| Insulin Signaling Pathway antibodies | Insulin Signaling Pathway Diagram |
| MAPK Signaling Pathway antibodies | MAPK Signaling Pathway Diagram |
| MAPK Signaling Pathway antibodies | MAPK Signaling Pathway Diagram |
| MAPK Signaling Pathway antibodies | MAPK Signaling Pathway Diagram |
| TNF Receptor Signaling Pathway antibodies | TNF Receptor Signaling Pathway Diagram |
Diseases associated with anti-NGK antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >16 publications with NGK and Neoplasms |
| Necrosis Antibodies | >12 publications with NGK and Necrosis |
| Inflammation Antibodies | >9 publications with NGK and Inflammation |
| Cell Transformation, Neoplastic Antibodies | >3 publications with NGK and Cell Transformation, Neoplastic |
| Liver Diseases Antibodies | >3 publications with NGK and Liver Diseases |
| Neoplasms, Experimental Antibodies | >3 publications with NGK and Neoplasms, Experimental |
| Carcinoma, Hepatocellular Antibodies | >2 publications with NGK and Carcinoma, Hepatocellular |
| Lung Diseases Antibodies | >2 publications with NGK and Lung Diseases |
| Glioma Antibodies | >2 publications with NGK and Glioma |
| Brain Diseases Antibodies | >2 publications with NGK and Brain Diseases |