NS-1619 [153587-01-0]
Cat# T3102-25mg
Size : 25mg
Brand : TargetMol
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NS-1619
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NS1619 have cardio-protective effects after ischemia-reperfusion injury.
Cas No. 153587-01-0
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98%
Color:White
Product Introduction
NS-1619 AI Summary
NS-1619 demonstrates a wide range of bioactivities across various biological systems and assays. It acts as an activator of maxi-K (BK) channels expressed in Xenopus laevis oocytes and CHO-K1 cells, showing significant increases in channel opening at concentrations of 20 uM and 30 uM, respectively. This includes a notable 325.2% relative increase in ionic current in CHO-K1 cells and a 116.0% increase in outward current in Xenopus laevis oocytes. The compound also induces BK channel-mediated vasorelaxation in KCl-induced contraction in Wistar rat aorta, with an Emax of up to 94.0% and IC50 values ranging from 4365.16 nM to 5888.44 nM. Additionally, NS-1619 exhibits protective effects against Bacillus anthracis lethal toxin in mouse RAW264.7 cells, increasing cell viability by 2.8-fold compared to controls. It has antiplasmodial activity against Plasmodium falciparum strains and demonstrates binding affinity to the Hsp90alpha N-terminal ATPase domain with an IC50 of 3320 nM. The compound also exhibits high plasma protein binding activity in mouse, human, and rat plasma samples, with PPB values exceeding 99.79%. Collectively, these findings highlight NS-1619's potential therapeutic applications in various disease pathways and cellular processes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NS1619 have cardio-protective effects after ischemia-reperfusion injury. |
| Targets & IC50 | BKCa channel:32 microM(ec50) |
| Molecular Weight | 362.23 |
| Formula | C15H8F6N2O2 |
| Cas No. | 153587-01-0 |
| Smiles | Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F |
| Relative Density. | 1.563 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (138.03 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||