P2Y12 Antibody
Cat# MBS540348-0,1mg
Size : 0.1mg
Brand : MyBiosource
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Phone : +1 850 650 7790
P2Y12 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540348MBS540348 is an antibody targeting P2Y12. Also known as P2Y12 Antibody. Reactive in Chimpanzee, Human, Monkey, Rat. Host: Rabbit. Affinity Purified P2Y purinoceptor 12 Antibody More details
Product Overview
Online Datasheet in PDFProduct Name
P2Y12, Polyclonal Antibody
Full Product Name
P2Y12 Antibody
Product Gene Name
anti-P2Y12 antibody
Product Synonym Names
ADP glucose receptor; ADPG R; ADPGR; BDPLT8; G protein coupled receptor SP1999; Gi coupled ADP receptor HORK 3; HORK 3; P2RY 12; P2T(AC); P2Y 12; P2Y purinoceptor 12; P2Y(ADP); P2Y(cyc); P2Y12; P2Y12 platelet ADP receptor; Platelet ADP receptor; Purinergic receptor P2RY12; Purinergic receptor P2Y G protein coupled 12; Purinergic receptor P2Y12; Putative G protein coupled receptor; SP 1999 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chimpanzee, Human, Monkey, Rat
Purity/Purification
Affinity Purified Immunoglobulins
Concentration
100 ug antibody in 175-200 ul antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
P2Y12 peptide (MBS544095) is used for blocking the activity of P2Y12 antibody (MBS540348)
Applications Tested/Suitable for anti-P2Y12 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-P2Y12 antibody
Confocal Microscopy: 1:100
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
Other Notes
Small volumes of anti-P2Y12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for P2Y12. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
P2Y purinoceptor 12
NCBI Official Synonym Full Names
purinergic receptor P2Y12
NCBI Official Symbol
P2RY12
NCBI Official Synonym Symbols
HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
UniProt Protein Name
P2Y purinoceptor 12
UniProt Synonym Protein Names
ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999
Protein Family
P2Y purinoceptor
UniProt Gene Name
P2RY12
UniProt Synonym Gene Names
HORK3; P2Y12; ADPG-R; P2Y(ADP)
UniProt Entry Name
P2Y12_HUMAN
NCBI Protein Information
P2Y purinoceptor 12
NCBI Summary for P2Y12
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Show more UniProt Comments for P2Y12
P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Mitochondrial; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: basal plasma membrane; caveola; cell surface; external side of plasma membrane; integral to plasma membrane; intrinsic to membrane; mitochondrion; plasma membrane
Molecular Function: adenosine receptor activity, G-protein coupled; guanyl-nucleotide exchange factor activity; platelet ADP receptor activity
Biological Process: adenosine receptor signaling pathway; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; glial cell migration; hemostasis; negative regulation of cell differentiation; positive regulation of GTPase activity; positive regulation of ion transport; protein kinase B signaling cascade; regulation of calcium ion transport; substrate-bound cell migration, cell extension
Disease: Bleeding Disorder, Platelet-type, 8
Show more Protein type: Membrane protein, multi-pass; GPCR, family 1; Mitochondrial; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: basal plasma membrane; caveola; cell surface; external side of plasma membrane; integral to plasma membrane; intrinsic to membrane; mitochondrion; plasma membrane
Molecular Function: adenosine receptor activity, G-protein coupled; guanyl-nucleotide exchange factor activity; platelet ADP receptor activity
Biological Process: adenosine receptor signaling pathway; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; glial cell migration; hemostasis; negative regulation of cell differentiation; positive regulation of GTPase activity; positive regulation of ion transport; protein kinase B signaling cascade; regulation of calcium ion transport; substrate-bound cell migration, cell extension
Disease: Bleeding Disorder, Platelet-type, 8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-P2Y12 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| ADP Signalling Through P2Y Purinoceptor 12 Pathway antibodies | ADP Signalling Through P2Y Purinoceptor 12 Pathway Diagram |
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| GPCRs, Class A Rhodopsin-like Pathway antibodies | GPCRs, Class A Rhodopsin-like Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
| Nucleotide-like (purinergic) Receptors Pathway antibodies | Nucleotide-like (purinergic) Receptors Pathway Diagram |
| P2Y Receptors Pathway antibodies | P2Y Receptors Pathway Diagram |
| Platelet Activation Pathway antibodies | Platelet Activation Pathway Diagram |
Diseases associated with anti-P2Y12 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Brain Diseases Antibodies | >42 publications with P2Y12 and Brain Diseases |
| Inflammation Antibodies | >30 publications with P2Y12 and Inflammation |
| Disease Models, Animal Antibodies | >18 publications with P2Y12 and Disease Models, Animal |
| Kidney Diseases Antibodies | >14 publications with P2Y12 and Kidney Diseases |
| Hypertension Antibodies | >10 publications with P2Y12 and Hypertension |
| Necrosis Antibodies | >7 publications with P2Y12 and Necrosis |
| Liver Diseases Antibodies | >5 publications with P2Y12 and Liver Diseases |
| Liver Neoplasms Antibodies | >2 publications with P2Y12 and Liver Neoplasms |
| Lung Neoplasms Antibodies | >2 publications with P2Y12 and Lung Neoplasms |
| Neoplasms, Experimental Antibodies | >2 publications with P2Y12 and Neoplasms, Experimental |
Organs/Tissues associated with anti-P2Y12 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Heart Antibodies | >82 publications with P2Y12 and Heart |
| Brain Antibodies | >42 publications with P2Y12 and Brain |
| Muscle Antibodies | >16 publications with P2Y12 and Muscle |
| Kidney Antibodies | >16 publications with P2Y12 and Kidney |
| Bone Antibodies | >13 publications with P2Y12 and Bone |
| Liver Antibodies | >11 publications with P2Y12 and Liver |
| Ovary Antibodies | >11 publications with P2Y12 and Ovary |
| Lung Antibodies | >9 publications with P2Y12 and Lung |
| Embryonic Tissue Antibodies | >3 publications with P2Y12 and Embryonic Tissue |
| Eye Antibodies | >2 publications with P2Y12 and Eye |
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