para-Nitroblebbistatin [1621326-32-6]
Cat# T12360-10mg
Size : 10mg
Brand : TargetMol
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para-Nitroblebbistatin
(Synonyms: p-Nitroblebbistatin) Copy Product Info
para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II. para-Nitroblebbistatin can be used to study the specific roles of myosin II in physiology, development, and cell biology.
Cas No. 1621326-32-6
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Purity:99.84%
Appearance:Solid
Color:Orange
COA LCMS HNMR
Product Introduction
para-Nitroblebbistatin AI Summary
para-Nitroblebbistatin exhibits moderate apparent permeability in human Caco2 cells, with Papp values of 32.5 x 10^-6 cm/s from the apical to basolateral side and 2.23 x 10^-6 cm/s from the basolateral to apical side. It demonstrates good drug recovery, achieving 34.0% recovery from the apical to basolateral side and 72.0% recovery from the basolateral to apical side in Caco2 cells. The compound shows relatively high aqueous solubility in pH 7.4 PBS, with a concentration of 31700.0 nM after 24 hours. Additionally, para-Nitroblebbistatin is photostable, with a half-life greater than 1.5 hours under irradiation at 390 to 470 nm in a DMSO/H2O solvent. Regarding bioactivity, para-Nitroblebbistatin inhibits rabbit skeletal muscle myosin 2 with an IC50 of 400.0 nM, and Dictyostelium discoideum myosin 2 ATPase activity with an IC50 of 2300.0 nM in NADH-coupled assays. It also acts as an inhibitor of actin-activated rabbit skeletal muscle myosin 2 with an IC50 of 500.0 nM and of actin-activated bovine heart muscle myosin 2 with an IC50 of 2100.0 nM. The selectivity ratio of IC50 for bovine heart muscle myosin 2 to rabbit skeletal muscle myosin 2 is 4.2, indicating some level of target selectivity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II. para-Nitroblebbistatin can be used to study the specific roles of myosin II in physiology, development, and cell biology. |
| In vitro | METHODS: HeLa cells were treated with para-Nitroblebbistatin (p-Nitroblebbistatin) (20 μM, 3 days) and the changes in cell number and death rate were tracked. RESULTS para-Nitroblebbistatin effectively inhibited cytokinesis and had no effect on cell number and death rate. [1] |
| Synonyms | p-Nitroblebbistatin |
| Molecular Weight | 337.33 |
| Formula | C18H15N3O4 |
| Cas No. | 1621326-32-6 |
| Smiles | Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccc(cc1)[N+]([O-])=O |
| Relative Density. | 1.47 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (74.11 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||