Parathyroid Hormone Receptor 1 (PTH1R) Human Recombinant Protein
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SKU
TP726881
Recombinant Human Parathyroid Hormone 1 Receptor/PTH1R (Gly49, C-6His)
Other products for "Parathyroid Hormone Receptor 1"
cDNA Clones
Lentiviral
AAV
CRISPR
RNAi
Proteins
Antibodies
Specifications
Product Data
Species
Human
Protein Source
Human
Expression cDNA Clone or AA Sequence
Protein Sequence
Tyr23-Met189
Tag
C-His
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Reconstitution Method
Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Always centrifuge tubes before opening. Do not mix by vortex or pipetting
Note
Recombinant Human Parathyroid hormone 1 receptor is produced by our Mammalian expression system and the target gene encoding Tyr23-Met189 is expressed with a 6His tag at the C-terminus.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Parathyroid hormone 1 receptor(PTH1R) is a multi-pass membrane protein. The protein is expressed in high levels in bone and kidney and regulates calcium ionhomeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
