Biovalley > Prolactin Protein
Prolactin Protein
Brand : Aviva Systems Biology
Prolactin Protein (OPPA00585)
| Datasheets/Manuals | Printable datasheet for Prolactin Protein (OPPA00585) |
|---|
| Predicted Species Reactivity | Rat |
|---|---|
| Product Format | The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM sodium Phosphate buffer pH=8 and 50mM Nacl. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder. |
| Host | E. Coli |
| Additional Information | Solubility: It is recommended to reconstitute the lyophilized Prolactin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. |
| :: | Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065 ng/ml. |
| :: | Product Introduction: Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation. Product Description: Prolactin Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.6 kDa. The Prolactin is purified by proprietary chromatographic techniques. |
| Reconstitution and Storage | Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Prolactin should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Peptide Sequence | The sequence of the first five N - terminal amino acids was determined and was found to be Met - Leu - Pro - Val - Cys. |
| Gene Symbol | rProlactin |
|---|---|
| Alias Symbols | Gha1, PRLB, Prol, PRLSD1, Prl1a1, RNPROL, RATPRLSD1 |
| NCBI Gene Id | 24683 |
| Protein Name | Prolactin |
| Description of Target | Recombinant Rat Prolactin |
| Uniprot ID | P01237 |
| Protein Accession # | NP_036761.1 |
| Protein Size (# AA) | Recombinant |
Biological pathways
| Name | # of Products |
|---|---|
| Cellular response to hormone stimulus | 15 |
| Circadian rhythm | 37 |
| Lactation | 57 |
| Multicellular organismal response to stress | 15 |
| Ovulation cycle | 5 |
| Parturition | 16 |
| Positive regulation of epithelial cell proliferation | 124 |
| Regulation of ossification | 7 |
| Response to drug | 235 |
| Response to estradiol stimulus | 85 |
| Response to ethanol | 77 |
| Response to lipopolysaccharide | 112 |
| Response to nutrient | 51 |
| Response to organic cyclic compound | 59 |
Biological process
| Name | # of Products |
|---|---|
| Cellular response to hormone stimulus | 35 |
| Circadian rhythm | 42 |
| Lactation | 44 |
| Mammary gland development | 47 |
| Multicellular organismal response to stress | 9 |
| Ovulation cycle | 10 |
| Parturition | 9 |
| Positive regulation of cell proliferation | 483 |
| Positive regulation of epithelial cell proliferation | 82 |
| Positive regulation of JAK-STAT cascade | 38 |
| Regulation of JAK-STAT cascade | 5 |
| Regulation of multicellular organism growth | 31 |
| Regulation of ossification | 13 |
| Response to drug | 323 |
| Response to estradiol stimulus | 102 |
| Response to ethanol | 105 |
| Response to lipopolysaccharide | 175 |
| Response to nutrient | 95 |
| Response to organic cyclic compound | 128 |
| STAT protein import into nucleus | 14 |
Cellular components
| Name | # of Products |
|---|---|
| Extracellular region | 1573 |
| Secretory granule | 77 |
Protein function
| Name | # of Products |
|---|---|
| Hormone activity | 494 |
| Prolactin receptor binding | 47 |


