rabbit Anti-IGFBP3 (Insulin Like Growth Factor Binding Protein 3, BP53, IBP3, Growth Hormone-Dependent Binding Protein, Acid Stable Subunit Of The 140 K IGF Complex) Polyclonal Antibody
Cat# 363591-200ul
Size : 200ul
Brand : US Biological
Contact local distributor :
Phone : +1 850 650 7790
363591 IGFBP3 (Insulin Like Growth Factor Binding Protein 3, BP53, IBP3, Growth Hormone-Dependent Binding Protein, Acid Stable Subunit Of The 140 K IGF Complex)
Clone Type
PolyclonalHost
rabbitSource
porcineSwiss Prot
P17936Isotype
IgGGrade
Affinity PurifiedApplications
WBCrossreactivity
PoShipping Temp
Blue IceStorage Temp
-20°C
The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
IGFBP3 protein levels decrease during the progression of prostate cancer from benign prostatic hyperplasia (BPH) to its metastatic form. Although, production of the protein does not cease completely. IGFBP3 is still made (at a lower level) by prostate cancer cells and secreted into the surrounding environment. However, instead of the full length, functional protein, IGFBP3 is found to be cleaved.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.