Recombinant Human RPE-retinal G protein-coupled receptor (RGR)
Cat# MBS7028528-0,1mg
Size : 0.1mg
Brand : MyBiosource
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RPE-Retinal G Protein-Coupled Receptor (RGR) Human Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7028528MBS7028528 is a recombinant protein targeting RGR. Also known as Recombinant Human RPE-retinal G protein-coupled receptor (RGR). Host: Cell Free Expression. More details
Product Overview
Product Name
RPE-retinal G protein-coupled receptor (RGR), Recombinant Protein
Full Product Name
Recombinant Human RPE-retinal G protein-coupled receptor (RGR)
Product Gene Name
RGR recombinant protein
Sequence
MAETSALPTG FGELEVLAVG MVLLVEALSG LSLNTLTIFS FCKTPELRTP CHLLVLSLAL ADSGISLNAL VAATSSLLRR WPYGSDGCQA HGFQGFVTAL ASICSSAAIA WGRYHHYCTR SQLAWNSAVS LVLFVWLSSA FWAALPLLGW GHYDYEPLGT CCTLDYSKGD RNFTSFLFTM SFFNFAMPLF ITITSYSLME QKLGKSGHLQ VNTTLPARTL LLGWGPYAIL YLYAVIADVT SISPKLQMVP ALIAKMVPTI NAINYALGNE MVCRGIWQCL SPQKREKDRT K
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Molecular Weight
27,728 Da
Sequence Positions
1-291aa; Full length protein
OMIM
600342
Species
Human
Product Categories/Family for RGR recombinant protein
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Application Notes for RGR recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Other Notes
Small volumes of RGR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for RGR. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
RPE-retinal G protein-coupled receptor isoform 2
NCBI Official Synonym Full Names
retinal G protein coupled receptor
NCBI Official Symbol
RGR
NCBI Official Synonym Symbols
RP44
UniProt Protein Name
RPE-retinal G protein-coupled receptor
Protein Family
RPE-retinal G protein-coupled receptor
UniProt Gene Name
RGR
UniProt Entry Name
RGR_HUMAN
NCBI Protein Information
RPE-retinal G protein-coupled receptor
NCBI Summary for RGR
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for RGR
RGR: Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. Defects in RGR are the cause of retinitis pigmentosa type 44 (RP44). RP44 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q23
Cellular Component: integral to plasma membrane
Molecular Function: G-protein coupled receptor activity; photoreceptor activity; protein binding
Biological Process: G-protein coupled receptor protein signaling pathway; phototransduction; protein-chromophore linkage; visual perception
Disease: Retinitis Pigmentosa 44
Show more Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q23
Cellular Component: integral to plasma membrane
Molecular Function: G-protein coupled receptor activity; photoreceptor activity; protein binding
Biological Process: G-protein coupled receptor protein signaling pathway; phototransduction; protein-chromophore linkage; visual perception
Disease: Retinitis Pigmentosa 44
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with RGR recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Opsins Pathway antibodies | Opsins Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By GPCR Pathway antibodies | Signaling By GPCR Pathway Diagram |
Diseases associated with RGR recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| Retinal Diseases Antibodies | >17 publications with RGR and Retinal Diseases |
| Retinitis Pigmentosa Antibodies | >11 publications with RGR and Retinitis Pigmentosa |
| Body Weight Changes Antibodies | >9 publications with RGR and Body Weight Changes |
| Death Antibodies | >9 publications with RGR and Death |
| Cell Transformation, Neoplastic Antibodies | >7 publications with RGR and Cell Transformation, Neoplastic |
| Disease Models, Animal Antibodies | >7 publications with RGR and Disease Models, Animal |
| Weight Loss Antibodies | >4 publications with RGR and Weight Loss |
| Hemorrhage Antibodies | >3 publications with RGR and Hemorrhage |
| Kidney Diseases Antibodies | >3 publications with RGR and Kidney Diseases |
| Neoplasm Metastasis Antibodies | >2 publications with RGR and Neoplasm Metastasis |
Organs/Tissues associated with RGR recombinant protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Eye Antibodies | >55 publications with RGR and Eye |
| Brain Antibodies | >11 publications with RGR and Brain |
| Connective Tissue Antibodies | >5 publications with RGR and Connective Tissue |
| Muscle Antibodies | >3 publications with RGR and Muscle |