Rifabutin [72559-06-9]
Cat# T1501-1ml
Size : 1mLx10mM(inDMSO)
Brand : TargetMol
Contact local distributor :
Phone : +1 850 650 7790
Rifabutin
(Synonyms: LM-427, Ansamycin) Copy Product Info
Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
Cas No. 72559-06-9
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:99.7%
Color:Red to Purple
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. |
| In vitro | In chimeric mice, the combined use of Rifabutin (100 mg/kg) and emtricitabine (10 mg/kg) resulted in a 75% survival rate among mice infected with either Toxoplasma or Plasmodium. Additionally, in these mice, Rifabutin significantly increased human CYP3A4 mRNA expression (by 7.4-fold), CYP3A4 protein levels (by 3.0-fold), testosterone 6β-hydroxylase activity (by 2.4-fold), and dexamethasone 6-hydroxylase activity (by 1.9-fold). |
| In vivo | Rifabutin exhibits broad-spectrum antimicrobial activity and, compared to rifampicin, demonstrates higher potency in vitro against the Mycobacterium avium complex (MAC), Mycobacterium tuberculosis, and Mycobacterium leprae. It is also effective against Group A Streptococcus, Campylobacter jejuni, Neisseria gonorrhoeae, Haemophilus influenzae, Staphylococcus species, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Chlamydia trachomatis, and Toxoplasma gondii. While rifabutin is active against most atypical mycobacteria, including Mycobacterium kansasii, it is less effective against Mycobacterium chelonae. Its isoenzyme selectivity closely resembles that of rifampicin, although rifampin induces to a greater extent, by 2-4 times. Furthermore, rifabutin enhances the glucuronidation of β-estradiol, 4-hydroxytamoxifen, and 1-naphthol by 2-3 times. |
| Synonyms | LM-427, Ansamycin |
| Molecular Weight | 847.00 |
| Formula | C46H62N4O11 |
| Cas No. | 72559-06-9 |
| Smiles | CO[C@H]1\C=C/O[C@@]2(C)Oc3c(C2=O)c2C4=NC5(CCN(CC(C)C)CC5)NC4=C(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(=O)c2c(O)c3C |
| Relative Density. | 1.339g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 38.00 mg/mL (44.86 mM), Sonication is recommended. DMSO: 50.00 mg/mL (59.03 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (2.36 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||