SARS-CoV-2 S-Protein ACE2 Binding Domain Antibody
Cat# bsm-70256M
Size : 100uL
Brand : Bioss
Contact local distributor :
Phone : +1 850 650 7790
Applications
Reactivity
| Overview | |
| Catalog # | bsm-70256M |
| Product Name | SARS-CoV-2 S-Protein ACE2 Binding Domain Antibody |
| Applications | WB |
| Specificity | Specific for the ~25 kDa ACE2 binding domain construct of SARS-CoV-2 S protein. Full-length CoV-2 S protein is ~142 kDa. |
| Reactivity | SARS-CoV-2 |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Source | Recombinant SARS-CoV-2 S-Protein construct containing the ACE2 binding domain expressed in and purified from E. coli. |
| Clonality | Monoclonal |
| Clone # | 5G8 |
| Isotype | IgG1 |
| Concentration | Lot Dependent |
| Purification | Purified by Protein G. |
| Storage Buffer | PBS + 50% glycerol and 5 mm NaN3 |
| Storage Condition | Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C. |
| Target | |
| Swiss Prot | P0DTC2 |
| Background | The novel SARS-coronavirus 2 (SARS-CoV-2) which causes the disease COVID-19 has been shown to utilize the SARS-CoV receptor ACE2 for entry into human cells (Hoffman, M. et al., Cell 2020). The entry of a coronavirus into host cells is mediated by the viral surface-anchored transmembrane spike (S) glycoprotein which is composed of two functional subunits, S1 which binds the receptor and S2 which fuses the membrane (Walls, AC et.al., Cell 2020). S1 contains a receptor-binding domain (RBD) which specifically recognizes ACE2 as its receptor (Wan, Y. et al., 2020). |
| Application Dilution | |
| WB | 1:300-5000 |