A selective, competitive antagonist of GABAA receptor (IC50 = 440nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100uM). Also shown to block glycine receptors, but with low affinity (Kb = 190uM).

Synonyms:
Gabazine; GABAA Receptor Antagonist; SR-95531; 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid, monohydrobromide

CAS No:
104104-50-9

Molecular Formula:
C15H17N3O3 • HBr

Molecular Weight:
368.23

Appearance:
White solid

Purity:
≥98% (HPLC)

Primary Target:
GABA-A

Primary Target IC50:
440nM

Proton NMR:
Conforms to structure

Elemental Analysis:
C% :47.50-50.50%
H%: 4.00-6.00%
N%: 10.00-13.00%

Water Molecules:
≤1.0mol

Solubility:
Water (25mM); MeOH:PBS (pH 7.2); (1:1): 0.5mg/ml; Methanol: 1mg/ml

Storage and Stability:
Lyophilized powder may be stored at 4°C Do not freeze. Stable for 6 months after receipt at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.