TET2 Antibody
Cat# MBS9603317-0,1mL
Size : 0.1mL
Brand : MyBiosource
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Phone : +1 850 650 7790
MBS9603317 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Western blot analysis of extracts of HL-60 cells, using TET2 antibody.
TET2 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9603317Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also… More details
Product Overview
Online Datasheet in PDFProduct Name
TET2, Polyclonal Antibody
Full Product Name
TET2 Antibody
Product Gene Name
anti-TET2 antibody
Product Synonym Names
FLJ20032; KIAA1546; MDS; Methylcytosine dioxygenase TET2; Nbla00191; Probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Tet 2; Tet methylcytosine dioxygenase 2; Tet oncogene 2; Tet oncogene family member 2; TET2; TET2_HUMAN
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
TET2 antibody detects endogenous levels of TET2.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
TET2 peptide (MBS9620794) is used for blocking the activity of TET2 antibody (MBS9603317)
Molecular Weight
Observed: 130 kDa; 133 kDa; 224 kDa
Predicted: 224 kDa
Predicted: 224 kDa
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human TET2.
Tissue Specificity
Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.
Predicted Cross Reactivity
Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus
Similarity
Zebrafish (100%), Bovine (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TET2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TET2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunohistochemistry (IHC) of anti-TET2 antibody
MBS9603317 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Other Notes
Small volumes of anti-TET2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for TET2 purchase
MBS9603317 is an antibody targeting TET2. Also known as TET2 Antibody. Reactive in Human, Mouse. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for TET2. It may not necessarily be applicable to this product.
NCBI Official Full Name
methylcytosine dioxygenase TET2 isoform a
NCBI Official Synonym Full Names
tet methylcytosine dioxygenase 2
NCBI Official Symbol
TET2
NCBI Official Synonym Symbols
MDS; KIAA1546
UniProt Protein Name
Methylcytosine dioxygenase TET2
Protein Family
Methylcytosine dioxygenase
UniProt Gene Name
TET2
UniProt Synonym Gene Names
KIAA1546
NCBI Protein Information
methylcytosine dioxygenase TET2
NCBI Summary for TET2
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Show more UniProt Comments for TET2
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-TET2 antibody
| Reference Product | PubMed Publications |
|---|---|
| ASXL1 antibody | >139 publications with TET2 and ASXL1 |
| IDH1 antibody | >120 publications with TET2 and IDH1 |
| JAK2 antibody | >111 publications with TET2 and JAK2 |
| DNMT3A antibody | >97 publications with TET2 and DNMT3A |
| EZH2 antibody | >81 publications with TET2 and EZH2 |
| IDH2 antibody | >70 publications with TET2 and IDH2 |
| RUNX1 antibody | >55 publications with TET2 and RUNX1 |
| PRMT5 antibody | >2 publications with TET2 and PRMT5 |
| SH2B3 antibody | >1 publications with TET2 and SH2B3 |
Pathways associated with anti-TET2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Epigenetic Regulation Of Gene Expression Pathway antibodies | Epigenetic Regulation Of Gene Expression Pathway Diagram |
| Gene Expression Pathway antibodies | Gene Expression Pathway Diagram |
| TET1,2,3 And TDG Demethylate DNA Pathway antibodies | TET1,2,3 And TDG Demethylate DNA Pathway Diagram |
Diseases associated with anti-TET2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Leukemia, Myeloid, Acute Antibodies | >146 publications with TET2 and Leukemia, Myeloid, Acute |
| Myelodysplastic Syndromes Antibodies | >114 publications with TET2 and Myelodysplastic Syndromes |
| Anemia Antibodies | >24 publications with TET2 and Anemia |
| Bone Diseases Antibodies | >13 publications with TET2 and Bone Diseases |
| Abnormalities, Multiple Antibodies | >6 publications with TET2 and Abnormalities, Multiple |
| Lymphoma, T-Cell, Peripheral Antibodies | >6 publications with TET2 and Lymphoma, T-Cell, Peripheral |
| Fibrosis Antibodies | >5 publications with TET2 and Fibrosis |
| Breast Neoplasms Antibodies | >5 publications with TET2 and Breast Neoplasms |
| Prostatic Neoplasms Antibodies | >5 publications with TET2 and Prostatic Neoplasms |
| Inflammation Antibodies | >3 publications with TET2 and Inflammation |
Organs/Tissues associated with anti-TET2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >115 publications with TET2 and Blood |
| Bone Marrow Antibodies | >66 publications with TET2 and Bone Marrow |
| Brain Antibodies | >20 publications with TET2 and Brain |
| Prostate Antibodies | >12 publications with TET2 and Prostate |
| Muscle Antibodies | >9 publications with TET2 and Muscle |
| Lung Antibodies | >5 publications with TET2 and Lung |
| Spleen Antibodies | >3 publications with TET2 and Spleen |
| Placenta Antibodies | >2 publications with TET2 and Placenta |
| Ascites Antibodies | >1 publications with TET2 and Ascites |
| Mouth Antibodies | >1 publications with TET2 and Mouth |