Tfrc rat monoclonal antibody, clone 8D3, Low Endotoxin
Size:
500 ug
Conjugation:
Unconjugated
View other "Tfrc or NP_035768.1" antibodies
Specifications
Product Data
Clone Name
8D3
Application
FC, FN, IHC
Recommended Dilution
Functional Assays. Dilute 1/100 - 1/200 Flow Cytometry: Use 10 µl of 1/100-1/200 diluted CD71 antibody to label 106 cells. Immunohistochemistry on Frozen Sections.
Reactivity
Mouse
Antibody Host
Rat
Isotype
IgG2a
Clonality
Monoclonal
Immunogen
Mouse transformed endothelioma cell line t.end1. Spleen cells from immunised Lewis rats were fused with the cells of the mouse NSO myeloma cell line
Specificity
This antibody recognises CD71, a 95kD cell surface protein that is otherwise known as transferrin receptor. This antibody recognises native, soluble and denatured forms of murine CD71. Binding of the 8D3 antibody to CD71 does not inhibit the proliferation of cell lines tested, and does not interfere with the uptake of iron into cells. The antibody has been used as a BBB transporter vector in mice and is suitable for studying CD71 expression, and iron uptake into different tissues, in the Mouse.
CD71 is a major iron-binding protein, which plays a key role in the transport of iron into cells that require it. In mice, CD71 is widely expressed on a variety of cells, including Sertoli cells and cells which form the blood brain barrier (BBB) in the central nervous system.
Synonyms
TfR1, p90, Transferrin receptor protein 1
Reference Data
Protein Categories
ADC Targets, CD Markers, Enzyme: Peptidases, Immune system diseases, Intracellular Proteins, Membrane Proteins, Secreated Proteins
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
