TNFA Antibody - C-terminal region
Cat# ARP44316_P050
Size : 100ul
Brand : Aviva Systems Biology
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TNF Antibody - C-terminal region (ARP44316_P050)
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| Datasheets/Manuals | Printable datasheet for anti-TNF (ARP44316_P050) antibody |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of Human TNFA |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 100%; Goat: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93% |
| Peptide Sequence | Synthetic peptide located within the following region: AVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLS |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-TNF (ARP44316_P050) antibody is Catalog # AAP44316 |
| Gene Symbol | TNF |
|---|---|
| Gene Full Name | tumor necrosis factor |
| Alias Symbols | DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha |
| NCBI Gene Id | 7124 |
| Protein Name | tumor necrosis factor |
| Description of Target | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| Uniprot ID | P01375 |
| Protein Accession # | NP_000585 |
| Protein Size (# AA) | 233 |
| Molecular Weight | 25kDa |
| Protein Interactions | LAMP2; CASP8; RNF8; FADD; RIPK1; TRADD; UBE2N; UBC; TRAF2; TNFRSF1A; RAB5A; HNRNPA1; CHUK; PSMD9; OTULIN; RNF31; TNFRSF1B; NFKBIA; LYN; FYN; YWHAQ; ZFP36; OPTN; RBCK1; IKBKG; TNFAIP3; HNRNPD; ELAVL1; SHARPIN; AGO2; HSPB2; HSPB1; MAP3K7; IKBKB; TAB2; TAB1; |
