Trichostatin A (TSA)

Cat# MBS8506609-5x5mg

Size : 5x5mg

Brand : MyBiosource

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TSA Inhibitor – Trichostatin A

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8506609

An antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture. TSA inhibited proliferation of eight breast carcinoma cell lines with mean +/-SD IC50 of 124.4 +/-120.4 nm (range, 26.4-308.1 nm). HDAC inhibitory activity of… More details

Product Overview

Online Datasheet in PDF
Product Name
Trichostatin A (TSA), Inhibitor
Full Product Name
Trichostatin A (TSA)
Product Gene Name
TSA, inhibitor
Purity/Purification
0.98
Preparation and Storage
Store at-20 degree C 2 years.
Molecular Weight
302.4
OMIM
600538
3D Structure
ModBase 3D Structure for P32119
Solubility
DMSO >=61mg/mL - Water <1mg/mL - Ethanol <1mg/mL
Formula
C17H22N2O3
CAS Number
58880-19-6

Product Categories/Family for TSA, inhibitor

Stem Cells; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Testing Data of TSA, inhibitor

TSA Inhibitor – Cat# MBS8506609

Other Notes

Small volumes of TSA, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSA purchase

MBS8506609 is an inhibitor targeting TSA. Also known as Trichostatin A (TSA).

Additional Details

NCBI/Uniprot data below describe general gene information for TSA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
TSA, partial
NCBI Official Synonym Full Names
peroxiredoxin 2
NCBI Official Symbol
PRDX2
NCBI Official Synonym Symbols
PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
UniProt Protein Name
Peroxiredoxin-2
UniProt Synonym Protein Names
Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1
Protein Family
Major surface-labeled trophozoite antigen
UniProt Gene Name
PRDX2
UniProt Synonym Gene Names
NKEFB; TDPX1; NKEF-B; TSA
NCBI Protein Information
peroxiredoxin-2

NCBI Summary for TSA

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
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UniProt Comments for TSA

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TSA, inhibitor

 Reference Product  PubMed Publications
 PRDX5 inhibitor  >11 publications with TSA and PRDX5
 CAT inhibitor  >4 publications with TSA and CAT
 SOD2 inhibitor  >3 publications with TSA and SOD2
 TXN inhibitor  >3 publications with TSA and TXN
 HSPD1 inhibitor  >2 publications with TSA and HSPD1

Pathways associated with TSA, inhibitor

 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram

Diseases associated with TSA, inhibitor

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >31 publications with TSA and Neoplasms
 Carcinoma Antibodies  >14 publications with TSA and Carcinoma
 Nervous System Diseases Antibodies  >8 publications with TSA and Nervous System Diseases
 Drug Toxicity Antibodies  >7 publications with TSA and Drug Toxicity
 Inflammation Antibodies  >6 publications with TSA and Inflammation
 Cardiovascular Diseases Antibodies  >5 publications with TSA and Cardiovascular Diseases
 Lung Diseases Antibodies  >5 publications with TSA and Lung Diseases
 Liver Diseases Antibodies  >5 publications with TSA and Liver Diseases
 Leukemia, Myeloid Antibodies  >4 publications with TSA and Leukemia, Myeloid
 Brain Diseases Antibodies  >4 publications with TSA and Brain Diseases

Organs/Tissues associated with TSA, inhibitor

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with TSA and Blood
 Vascular Antibodies  >12 publications with TSA and Vascular
 Brain Antibodies  >12 publications with TSA and Brain
 Liver Antibodies  >10 publications with TSA and Liver
 Muscle Antibodies  >8 publications with TSA and Muscle
 Eye Antibodies  >7 publications with TSA and Eye
 Heart Antibodies  >7 publications with TSA and Heart
 Kidney Antibodies  >6 publications with TSA and Kidney
 Bone Antibodies  >6 publications with TSA and Bone
 Lung Antibodies  >6 publications with TSA and Lung