U-73343 [142878-12-4]
Cat# TQ0159-5mg
Size : 5mg
Brand : TargetMol
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U-73343
(Synonyms: U 73343) Copy Product Info
U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
Cas No. 142878-12-4
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.06%
Appearance:Solid
Color:White
COA HPLC HNMR LCMS
Product Introduction
U-73343 AI Summary
U-73343 exhibits a range of bioactivities across various assays: it inhibits mitochondrial division or activates mitochondrial fusion, modulates the mTORC1 signaling pathway in cell-based assays, and affects cytosolic chaperonin activity. Additionally, it functions as both an allosteric agonist and antagonist of the Human D1 Dopamine Receptor. The compound inhibits T. brucei phosphofructokinase, Chronic Active B-Cell Receptor Signaling, ELG1-dependent DNA repair in HEK293T cells, and ATXN expression. Furthermore, it inhibits Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) and impedes Lassa Virus and Marburg Virus binding or entry into cells. Lastly, U-73343 enhances Arylsulfatase A (ASA1) activity and identifies Gametocytocidal compounds..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC. |
| Targets & IC50 | PA:1-2.1 µM |
| Synonyms | U 73343 |
| Molecular Weight | 466.66 |
| Formula | C29H42N2O3 |
| Cas No. | 142878-12-4 |
| Smiles | COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN1C(=O)CCC1=O |
| Relative Density. | 1.15 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.67 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||