ZM241385 [139180-30-6]
Cat# NB-64-38237-5mg
Size : 5mg
Brand : Neo Biotech
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Phone : +1 850 650 7790
ZM241385
Catalog No. T7021 Copy Product Info
Purity: 99.69%
ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
ZM241385
Copy Product InfoZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
Cas No. 139180-30-6
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor. |
| Targets&IC50 | A2A receptor:1.4 nM (Ki) |
| In vitro | ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7?min) OGD period, and protect CA1 neuron and astrocyte from injury[4]. |
| In vivo | ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1]. |
| Cell Research | Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dWater and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO. (Only for Reference) |
| Molecular Weight | 337.34 |
| Formula | C16H15N7O2 |
| Cas No. | 139180-30-6 |
| Smiles | Nc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1 |
| Relative Density. | 1.59 g/cm3 (Predicted) |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 1.7 mg/mL (5.04 mM), Sonication is recommended. DMSO: 120 mg/mL (355.72 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.82 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||
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