Webinar: Advancing drug screening and mechanism studies using TR-FRET

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Modern drug discovery requires assay technologies that are fast, reliable, and scalable. However, many conventional screening methods still face critical limitations, including labor-intensive multi-step workflows, significant background interference that compromises data consistency and reproducibility, and limited throughput that restricts both large-scale screening and in-depth mechanistic studies.

In this webinar, we will examine how Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) effectively addresses these challenges. By combining time-resolved detection with a homogeneous, mix-and-read assay format, TR-FRET enables highly sensitive and reproducible measurements while supporting high-throughput workflows.

The session will introduce the core principles of TR-FRET, explain its superior signal-to-background performance, and highlight practical applications across drug screening, functional assays, and mechanism-of-action studies. Attendees will discover how TR-FRET can simplify assay development, increase screening capacity, and improve confidence in experimental results.

Overview

TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) is a powerful homogeneous assay technology that combines the principles of time-resolved fluorescence with Förster resonance energy transfer. By using long-lifetime lanthanide donors and introducing a time delay before signal detection, TR-FRET dramatically reduces background interference from autofluorescence and light scattering, delivering an excellent signal-to-background ratio and high sensitivity.

Its mix-and-read format eliminates washing steps, simplifies workflows, and supports miniaturization and automation, making it ideal for high-throughput screening (HTS), functional assays, protein-protein interactions, kinase profiling, and mechanism-of-action studies. Attendees will gain practical insights into implementing TR-FRET to accelerate drug discovery programs while enhancing data quality and reproducibility.

Meet the Speaker

Idil Ariöz

Technical Supervisor, ACROBiosystems

Idil Ariöz is a scientific expert at ACROBiosystems, currently serving as Technical Supervisor for France, BeNeLux, and South Europe. She bridges advanced research with practical innovation in the biopharmaceutical sector by delivering tailored solutions, including custom product recommendations, troubleshooting support, and technical documentation that facilitates regulatory and operational success. She also actively promotes sustainable laboratory practices aligned with the industry’s evolving environmental goals.

Prior to her current role, Idil was a member of ACROBiosystems’ corporate development team, where she led strategic partnerships and collaborations with key organizations across the biotech, pharmaceutical, and academic ecosystems. Her contributions have helped shape high-impact alliances that drive innovation and expand the company’s global presence.

Key Takeaways

Core Principles of TR-FRET

Understand the fundamental mechanisms of time-resolved detection and homogeneous assay design, and how they overcome the limitations of traditional fluorescence-based methods.

Superior Performance Advantages

Discover how TR-FRET delivers exceptional signal-to-background ratios, high sensitivity, reproducibility, and suitability for miniaturized, high-throughput workflows without washing steps.

Practical Applications in Drug Discovery

Explore real-world examples of TR-FRET in drug screening, functional assays, kinase profiling, protein interaction studies, and mechanism-of-action investigations to accelerate and de-risk development programs.