Pyrazinamide [98-96-4]
Cat# T1426-500mg
Size : 500mg
Brand : TargetMol
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Pyrazinamide
(Synonyms: Pyrazinoic acid amide, Pyrazinecarboxamide) Copy Product Info
Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
Cas No. 98-96-4
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.95%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
Pyrazinamide AI Summary
Pyrazinamide exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Rv, with a minimum inhibitory concentration (MIC) ranging from 3.125 to 50.0 ug/mL depending on the assay method and conditions used. The compound has demonstrated varying efficacy across different media and pH levels, with its strongest activity recorded at 3.125 ug/mL using the microplate alamar blue assay. Additionally, Pyrazinamide shows some efficacy against multidrug-resistant Mycobacterium tuberculosis strains with MIC values up to 128.0 ug/mL. The compound also exhibits pharmacokinetic properties such as a half-life (T1/2) of approximately 6.6 to 6.9 hours and high plasma protein binding (>91%), indicating significant bioavailability and distribution in mammalian systems. While showing strong antimycobacterial activity, Pyrazinamide displays moderate to low cytotoxicity, as noted in HepG2 and Vero cells assays. These bioactivities suggest its potential as a candidate for further development in antitubercular drug research..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative. |
| Synonyms | Pyrazinoic acid amide, Pyrazinecarboxamide |
| Molecular Weight | 123.11 |
| Formula | C5H5N3O |
| Cas No. | 98-96-4 |
| Smiles | NC(=O)C1=NC=CN=C1 |
| Relative Density. | 1.3260 g/cm3 (Estimated) |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 2 mg/mL (16.25 mM), Sonication is recommended. DMSO: 20 mg/mL (162.46 mM), Sonication is recommended.  H2O: 16.67 mg/mL (135.41 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.25 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/H2O/DMSO
H2O/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||