Reagents and instruments for immunology, cell biology and molecular biology.
 
Adult Bovine Serum Alternative to FBS

Adult Bovine Serum Alternative to FBS

Adult Bovine Serum (ABS) is collected from cattle older than 12 months, usually at slaughter or from donor cows under controlled hygienic conditions. It is separated from blood via mechanical defibrination and stored frozen until use. ABS is used as a supplement in cell culture media similarly to the more common Fetal Bovine Serum (FBS), but it is less expensive.

Studies show that ABS can support cell growth and proliferation but generally requires a higher concentration than FBS to achieve comparable cell production. For instance, culturing BHK-21 cells in ABS-containing medium requires about 1.5 times more serum volume than FBS to achieve similar cell proliferation. The addition of specific protein extracts can synergistically enhance cell growth in ABS media.

Applications and Performance

One notable application of ABS was demonstrated in culturing Helicobacter pylori, where heat-treated adult bovine serum showed useful growth-supporting properties at a lower cost than FBS. The serum's bactericidal activity against H. pylori was inactivated by heat treatment, improving its suitability for culture media.

ABS also contains distinct serum factors that can regulate the differentiation of adipogenic precursor cells, differing from FBS in lipid, protein, and hormone content. These differences make ABS uniquely influential in certain cell differentiation processes.

Comparison to Fetal Bovine Serum

Compared to FBS, adult bovine serum has higher antibody levels and generally lower concentrations of growth factors, which affects its performance in supporting cell growth. Research into replacing FBS with adult serum or serum-free media is ongoing but challenging, as FBS contains a complex mixture of growth factors, hormones, and nutrients essential for many cell culture applications.

In summary, adult bovine serum serves as a cost-effective alternative to fetal bovine serum for cell culture, with some limitations in growth support that can be addressed by additives or higher concentrations. It is used in various research and industrial contexts, including bacterial culture and mammalian cell culture, with ongoing research into its components and applications.

Frequently Asked Questions (FAQ)

How can I quickly find a abs alternative to fbs product?

To find a abs alternative to fbs product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the abs alternative to fbs category?

Yes, Biovalley distributes several product references in the abs alternative to fbs category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for abs alternative to fbs products?

Yes, you can request a quote for abs alternative to fbs products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a abs alternative to fbs product is available to order?

The availability of a abs alternative to fbs product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the abs alternative to fbs product I am looking for?

If the abs alternative to fbs product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all abs alternative to fbs products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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