G-418 (geneticin) for cell culture
The antibiotic G-418, also known as geneticin, is a selective antibiotic of the aminoglycoside family. G-418, produced by the bacterium Micromonospora rhodorangea, has a similar structure to gentamicin B1 and has the same mode of action on ribosomes. The classically used form of gentamicin is its disulfate.
G-418 has the particularity of inhibiting protein synthesis not only on bacteria but also on eukaryotic cells on which it has a cytotoxic effect. G-418 is said to be a selective antibiotic because it is possible to confer resistance to this antibiotic through the neo gene (neomycin resistance gene) of the Tn5 transposon. The genetically modified cells then carry the geneticin resistance gene. Selection in mammalian cells is usually achieved within 3-7 days with concentrations ranging from 400 to 1000 µg/ml.
Frequently Asked Questions (FAQ)
How can I quickly find a g-418 product?
To find a g-418 product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.
Does Biovalley stock several product codes in the g-418 category?
Yes, Biovalley distributes several product references in the g-418 category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.
Can I request a quote for g-418 products?
Yes, you can request a quote for g-418 products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.
How can I find out if a g-418 product is available to order?
The availability of a g-418 product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.
What should I do if I cannot find the g-418 product I am looking for?
If the g-418 product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.
Are all g-418 products available under the same terms and conditions?
No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.
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