SARS-CoV-2 - Spike protein - Primary antibodies
The SARS-CoV-2 virus, the cause of the current Covid-19 pendemia, can infect human respiratory epithelial cells through an interaction with the human ACE2 receptor or angiotensin converting enzyme receptor 2. SARS-CoV-2 has on its surface a protein called Spike or S protein. This type I transmembrane protein is present on the viral envelope in the form of a homotrimer. Each monomer consists of 2 subunits, S1 and S2. The S1 subunit contains a receptor binding domain (RBD) which binds to the ACE2 receptor on the host membrane. The S2 sub-unit is activated by the bond between S1 and the ACE2 receptor and contains the elements necessary for membrane fusion. The S protein thus plays an important role in the infection of SARS-CoV-2 as well as in the induction of neutralizing antibody and T cell responses and in protective immunity.
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RUOCE / IVD
- Unconjugated 1917
- Biotin 87
- HRP 63
- FITC 20
- PE 4
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- virus 1270
- human 154
- mouse 76
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- monkey 4
- all species 3
- Primary antibody
- rabbit 917
- mouse 526
- human 489
- goat 24
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- plant 2
- sars-cov-2 2
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- rat 1
- virus 1
- ELISA 1788
- WB 851
- IF 279
- Neutralization 163
- IP 144
- ICC 124
- FC 116
- IHC 97
- Assay 47
- Dot blot 26
- Chemiluminescence 18
- FA 10
- Immunoassay 8
- Lateral Flow 6
- Chromatography 2
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- Polyclonal 565
- Monoclonal 388
- CR3022 37
- S 31
- D001 19
- AM122 18
- A1 15
- D004 15
- 5D9 13
- H6 13
- D006 12
- 7 10
- AM130 10
- CB6 10
- D003 10
- DM24 9
- DM25 9
- RH-01 9
- RH-02 9
- 5E8 8
- DM39 8
- DM40 8
- DM41 8
- 2146 7
- 2165 7
- 2196 7
- ABM19C9 7
- D005 7
- MAbs in vitro: R107 7
- MAbs in vivo: RBD1106 7
- OTI1H6 7
- OTI5A7 7
- R007 7
- RBD1125 7
- 118 6
- 34-G3 6
- 43 6
- Q25-L 6
- 16-F-28 5
- 19-J-16 5
- 23-D-12 5
- 27B12 5
- 38G5 5
- 49F9 5
- 4A3 5
- 5A7 5
- 6G7 5
- 71D2 5
- 79C3 5
- AM001414 (414-1) 5
- AM002414 (414-2) 5
- AM004414 (414-4) 5
- AM043105 (105-43) 5
- DM26 5
- DM27 5
- DM35 5
- DM42 5
- OTI1C2 5
- R00231-234 5
- R00240-242 5
- R00244-246 5
- R00247-250 5
- R00251-254 5
- R00263-266 5
- R00267-270 5
- R00271-274 5
- R00319-322 5
- R00323-326 5
- R00327-330 5
- R00331-334 5
- Recombinant 5
- 1G8D11 4
- 27C2 4
- 28H3 4
- 30C5 4
- 36A7 4
- 58F8 4
- 5E12 4
- 72A5 4
- 7A4D12 4
- 7C11H11 4
- 9F7E4 4
- ABM5D1.1E8 4
- AD10.F6.G3.E3 4
- AS35 4
- D002 4
- REGN10933 4
- REGN10987 4
- 001 3
- 003 3
- 05 3
- 1 3
- 117 3
- 135 3
- 17 3
- 18C7B10 3
- 190 3
- 1C3H9 3
- 20C3G5 3
- 2215 3
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