AirOtop® Enhanced Seals are high gas-exchange sterile flask sealing systems engineered to optimize oxygen transfer while maintaining contamination control during microbial cultivation workflows. Designed for shake flask cultures and compatible with both disposable and glass flasks, these sterile gas-permeable seals support improved aeration performance in microbial expression, recombinant protein production, plasmid manufacturing, and bioprocess development applications. Their combination of sterile barrier protection and enhanced gas transfer makes them particularly valuable for high-density microbial culture systems where oxygen availability can become growth limiting.

Utility of AirOtop® Enhanced Seals

• Support high-aeration microbial cultivation workflows including bacterial, yeast, algal, and recombinant expression systems.
• Enable sterile gas exchange during orbital shaker culture, helping maintain oxygen availability and culture performance.
• Provide a practical alternative to foil covers, cotton plugs, and traditional flask closures for scalable research workflows.
• Compatible with microbial scale-up workflows and high-density culture applications requiring improved aeration efficiency.

Key Features

• High gas-exchange design for improved oxygen transfer and enhanced microbial growth performance.
• Sterile 0.2 µm hydrophobic membrane barrier to minimize contamination risk while allowing gas permeability.
• Resealable gas-permeable membrane maintains culture accessibility for up to approximately 24 hours.
• Broad compatibility with Ultra Yield® Flasks and conventional glass or disposable shake flasks.
• Disposable, ready-to-use sterile format supporting simplified laboratory workflows and reduced preparation time.