CD41, CD61 (CD41b, GP2B, GP-IIb, GPIIb, GP3A, GP-IIIa, GPIIIa, GTA, HPA3, Integrin alpha 2b, ITGA2B, Integrin beta 3, ITGB3, Platelet Glycoprotein IIb of IIb/IIIa Complex) (APC)

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Cat# C2394-35B-APC-100ul

Size : 100ul

Contact local distributor :

Phone : +1 850 650 7790

Brand : US Biological

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Contact local distributor :

Phone : +1 850 650 7790

C2394-35B-APCCD41, CD61 (CD41b, GP2B, GP-IIb, GPIIb, GP3A, GP-IIIa, GPIIIa, GTA, HPA3, Integrin alpha 2b, ITGA2B, Integrin beta 3, ITGB3, Platelet Glycoprotein IIb of IIb/IIIa Complex) (APC)

Specifications

Clone TypeMonoclonal

Hostmouse

Sourcechicken

IsotypeIgG1

GradeAffinity Purified

ApplicationsFC IF IP

CrossreactivityCh

Shipping TempBlue Ice

Storage Temp4°C Do Not Freeze

CD41/61 is a heterodimeric cell surface protein that is expressed on chicken thrombocytes and cells of the thrombocyte lineage. Avian thrombocytes are nucleated equivalents of mammalian platelets that play a role in coagulation and phagocytosis.

Applications:
Suitable for use in Flow Cytometry, Immunofluorescence and Immunoprecipitation. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Hybridoma:
X63/A63-653 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

Applications

Product Type: Mab|Isotype: IgG1|Clone No: 10B1565 (11C3)|Host: mouse|Source: chicken|Concentration: As Reported|Form: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).|Purity: Purified by Protein G affinity chromatography from tissue culture supernatant.|Immunogen: Peripheral blood leukocytes from white leghorn chicken.|Specificity: Recognizes the chicken integrin CD41/61. Reported to induce thrombocyte activation.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Immunogen

Peripheral blood leukocytes from white leghorn chicken.

Form

Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).

Purity

Purified by Protein G affinity chromatography from tissue culture supernatant.

Specificity

Recognizes the chicken integrin CD41/61. Reported to induce thrombocyte activation.

References

1. Lacoste-Eleaume, A.S. et al. (1994) Biochemical and functional characterization of an Avian homolog of the integrin GPIIb-IIa present on chicken thrombocytes. Exp. Cell. Res. 213: 198 - 209. 2. Corbel, C. et al. (2002) Expression of alpha V beta 3 integrin in the chick embryo aortic endothelium. Int. J. Dev. 46: 827 - 830. 3. Del Cacho, E. et al. (2008) Isolation of chicken follicular dendritic cells. J Immunol Methods. 334: 59-69. 4. Del Cacho, E. et al. (2009) Avian follicular and interdigitating dendritic cells: isolation and morphologic, phenotypic, and functional analyses. Vet Immunol Immunopathol. 129: 66-75. 5. Ody, C. et al. (1999) Glycoprotein IIb-IIIa is expressed on avian multilineage hematopoietic progenitor cells. Blood. 93: 2898-906. 6. Chaussé, A.M. et al. (2011) Expression of Toll-like receptor 4 and downstream effectors in selected cecal cell subpopulations of chicks resistant or susceptible to Salmonella carrier state. Infect Immun. 79: 3445-54.