Reagents and instruments for immunology, cell biology and molecular biology.
 
Histone methylation assays

Histone methylation assays

Histone methylation assays detect methyl group additions on lysine and arginine residues, regulating chromatin organization and gene expression. These modifications generate activating or repressive marks depending on residue position and methylation state.

Core Methodologies

  • Western blotting: Uses site-specific antibodies to quantify histone methylation levels.
  • ELISA: Measures global or targeted methylation from nuclear extracts.
  • Chromatin immunoprecipitation (ChIP): Maps methylation patterns across genomic regions.
  • Mass spectrometry: Enables precise site-specific and combinatorial modification analysis.

Biological Roles

  • Mono-, di-, and tri-methylation states exert distinct regulatory functions.
  • H3K4me3 marks active promoters and transcription start sites.
  • H3K27me3 mediates repression via Polycomb complexes.
  • H3K9me2/3 establishes heterochromatin domains.
  • H3K36me3 associates with actively transcribed gene bodies.

Applications

  • Cancer research identifies aberrant methylation profiles.
  • Developmental biology tracks lineage-specific epigenetic states.
  • Drug screening evaluates methyltransferase and demethylase inhibitors.
  • Gene regulation studies correlate marks with transcriptional activity.
  • Stem cell research monitors differentiation processes.

Frequently Asked Questions (FAQ)

How can I quickly find a histone methylation assays product?

To find a histone methylation assays product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the histone methylation assays category?

Yes, Biovalley distributes several product references in the histone methylation assays category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for histone methylation assays products?

Yes, you can request a quote for histone methylation assays products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a histone methylation assays product is available to order?

The availability of a histone methylation assays product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the histone methylation assays product I am looking for?

If the histone methylation assays product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all histone methylation assays products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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